Reactome | Transport of antigen loaded MHC II molecules to surface

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Transport of antigen loaded MHC II molecules to surface Show undefined attributes

authored	[InstanceEdit:2132294] Garapati, P V, 2012-02-21
category	omitted
compartment	[Compartment:17938] lysosomal membrane [Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2213247] Garapati, P V, 2012-04-30
dbId	2213248
displayName	Transport of antigen loaded MHC II molecules to surface
edited	[InstanceEdit:2132294] Garapati, P V, 2012-02-21
eventOf	[Pathway:R-HSA-2132295] MHC class II antigen presentation - Homo sapiens
input	[DefinedSet:R-HSA-2228747] ARP-1 [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-2029135] Dynein:Dynactin:microtubule [cytosol] [Complex:R-HSA-2213219] Kinesins:Dynactin:microtubule [cytosol] [Complex:R-HSA-2213223] peptide loaded MHC class II [lysosomal membrane] [Complex:R-HSA-2213215] RAB7:RILP:ORP1L complex [lysosomal membrane] [EntityWithAccessionedSequence:R-HSA-420049] SPTBN2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2213136] Activation of endosomal dynein motors by stepwise assembly of Rab7-RILP-p150Glued, ORP1L, and the receptor betalll spectrin [LiteratureReference:2213142] B lymphocytes secrete antigen-presenting vesicles [LiteratureReference:2213121] Dendritic cell maturation triggers retrograde MHC class II transport from lysosomes to the plasma membrane [LiteratureReference:2213143] Direct vesicular transport of MHC class II molecules from lysosomal structures to the cell surface [LiteratureReference:2213146] MHC class II molecules on the move for successful antigen presentation [LiteratureReference:2213158] Opposing motor activities of dynein and kinesin determine retention and transport of MHC class II-containing compartments [LiteratureReference:2262772] Cholesterol sensor ORP1L contacts the ER protein VAP to control Rab7-RILP-p150 Glued and late endosome positioning
maxDepth	1
modified	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
name	Transport of antigen loaded MHC II molecules to surface
orthologousEvent	[BlackBoxEvent:R-SSC-2213248] Transport of antigen loaded MHC II molecules to surface - Sus scrofa [BlackBoxEvent:R-BTA-2213248] Transport of antigen loaded MHC II molecules to surface - Bos taurus [BlackBoxEvent:R-CFA-2213248] Transport of antigen loaded MHC II molecules to surface - Canis familiaris [BlackBoxEvent:R-RNO-2213248] Transport of antigen loaded MHC II molecules to surface - Rattus norvegicus [BlackBoxEvent:R-MMU-2213248] Transport of antigen loaded MHC II molecules to surface - Mus musculus
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-HSA-2228747] ARP-1 [cytosol] [Complex:R-HSA-2029135] Dynein:Dynactin:microtubule [cytosol] [Complex:R-HSA-2213219] Kinesins:Dynactin:microtubule [cytosol] [Complex:R-HSA-203463] MHC Class II bearing antigen peptide [plasma membrane] [Complex:R-HSA-2213215] RAB7:RILP:ORP1L complex [lysosomal membrane] [EntityWithAccessionedSequence:R-HSA-420049] SPTBN2 [cytosol]
precedingEvent	[Reaction:R-HSA-2213244] Loading of antigenic peptides - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2247930] Neefjes, Jacques, 2012-05-14 [InstanceEdit:9953420] May, Bruce, 2025-06-02
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-2213248
summation	[Summation:2213100] Once MHC class II-peptide complexes are formed, they must be...
updateTrackers	[UpdateTracker:9984636] Update Tracker - [BlackBoxEvent:2213248] Transport of antigen loaded MHC II molecules to surface - v96:[modifyText] [UpdateTracker:9953551] Update Tracker - [BlackBoxEvent:2213248] Transport of antigen loaded MHC II molecules to surface - v93:[add_removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9984636] Update Tracker - [BlackBoxEvent:2213248] Transport of antigen loaded MHC II molecules to surface - v96:[modifyText] [UpdateTracker:9953551] Update Tracker - [BlackBoxEvent:2213248] Transport of antigen loaded MHC II molecules to surface - v93:[add_removeOutput]
(hasEvent)	[Pathway:R-HSA-2132295] MHC class II antigen presentation

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