Reactome | STAB1 (FEEL-1) binds ligands

Schema > Reaction > Entries

STAB1 (FEEL-1) binds ligands Show undefined attributes

authored	[InstanceEdit:3000476] May, B, 2013-01-26 [InstanceEdit:3222522] Neyen, Claudine, 2013-03-22
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:2197769] May, B, 2012-04-14
dbId	2197770
displayName	STAB1 (FEEL-1) binds ligands
edited	[InstanceEdit:2197647] May, B, 2012-04-13
eventOf	[Pathway:R-HSA-3000497] Scavenging by Class H Receptors - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-2247513] STAB1:ligand is endocytosed - Homo sapiens
input	[DefinedSet:R-HSA-2197767] Ligands of STAB1 [extracellular region] [EntityWithAccessionedSequence:R-HSA-2197768] STAB1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2197732] FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products [LiteratureReference:2197749] FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities [LiteratureReference:2197727] Novel function of alternatively activated macrophages: stabilin-1-mediated clearance of SPARC [LiteratureReference:2197756] Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding [LiteratureReference:2197735] Stabilin-1 mediates phosphatidylserine-dependent clearance of cell corpses in alternatively activated macrophages [LiteratureReference:2197747] Stabilin-1/CLEVER-1, a type 2 macrophage marker, is an adhesion and scavenging molecule on human placental macrophages
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	STAB1 (FEEL-1) binds ligands
orthologousEvent	[Reaction:R-RNO-2197770] STAB1 (FEEL-1) binds ligands - Rattus norvegicus [Reaction:R-GGA-2197770] STAB1 (FEEL-1) binds ligands - Gallus gallus [Reaction:R-DRE-2197770] STAB1 (FEEL-1) binds ligands - Danio rerio [Reaction:R-SSC-2197770] STAB1 (FEEL-1) binds ligands - Sus scrofa [Reaction:R-BTA-2197770] STAB1 (FEEL-1) binds ligands - Bos taurus [Reaction:R-CFA-2197770] STAB1 (FEEL-1) binds ligands - Canis familiaris [Reaction:R-MMU-2197770] STAB1 (FEEL-1) binds ligands - Mus musculus
output	[Complex:R-HSA-2197764] STAB1:Ligand [plasma membrane]
releaseDate	2013-06-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3222522] Neyen, Claudine, 2013-03-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2197770
summation	[Summation:2213047] STAB1 (FEEL-1) binds acetylated low density lipoprotein (LDL...

Referrals

(hasEvent)	[Pathway:R-HSA-3000497] Scavenging by Class H Receptors
(precedingEvent)	[BlackBoxEvent:R-HSA-2247513] STAB1:ligand is endocytosed