STAB1 (FEEL-1) binds ligands

Stable Identifier
Reaction [binding]
Homo sapiens
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STAB1 (FEEL-1) binds acetylated low density lipoprotein (LDL) (Adachi & Tsujimoto 2002, Palani et al. 2011), phosphatidylserine (exposed when cells are lysed) (Park et al. 2009), advanced glycation end products (AGE) (Tamura et al. 2003, Hansen et al. 2005), and Osteonectin (SPARC) (Kzhyshkowska et al. 2006).
Literature References
PubMed ID Title Journal Year
16670288 Novel function of alternatively activated macrophages: stabilin-1-mediated clearance of SPARC

Goerdt, S, Arap, W, Gratchev, A, Krusell, L, Sage, EH, Cardó-Vila, M, Kzhyshkowska, J, Workman, G, Pasqualini, R

J Immunol 2006
15572036 Stabilin-1 and stabilin-2 are both directed into the early endocytic pathway in hepatic sinusoidal endothelium via interactions with clathrin/AP-2, independent of ligand binding

Goerdt, S, Smedsrød, B, Nedredal, GI, Kzhyshkowska, J, Falkowski, M, Elvevold, K, Schledzewski, K, Olsen, R, Hansen, B, Johansson, S, Johansson, S, Longati, P, McCourt, P, Carlsson, F

Exp Cell Res 2005
19726632 Stabilin-1 mediates phosphatidylserine-dependent clearance of cell corpses in alternatively activated macrophages

Kang, KB, Gratchev, A, Kim, IS, Kzhyshkowska, J, Lee, SJ, Jung, MY, Riabov, V, Park, SY

J Cell Sci 2009
12473645 FEEL-1 and FEEL-2 are endocytic receptors for advanced glycation end products

Tsujimoto, M, Sekiya, M, Ohashi, K, Nagai, R, Kimura, S, Tamura, Y, Yahagi, N, Tomita, S, Iizuka, Y, Okazaki, H, Shimano, H, Ishibashi, S, Osuga, J, Adachi, H

J Biol Chem 2003
12077138 FEEL-1, a novel scavenger receptor with in vitro bacteria-binding and angiogenesis-modulating activities

Tsujimoto, M, Adachi, H

J Biol Chem 2002
21480214 Stabilin-1/CLEVER-1, a type 2 macrophage marker, is an adhesion and scavenging molecule on human placental macrophages

Maksimow, M, Salmi, M, Miiluniemi, M, Palani, S, Jalkanen, S, Auvinen, K

Eur J Immunol 2011
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