Reactome | COQ2 ligates all-E-10PrP2 to PHB

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COQ2 ligates all-E-10PrP2 to PHB Show undefined attributes

authored	[InstanceEdit:2162344] Williams, MG, 2012-03-19
catalystActivity	[CatalystActivity:2162263] 4-hydroxybenzoate polyprenyltransferase activity of COQ2 [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70616] mitochondrial inner membrane [Compartment:5460] mitochondrial matrix
created	[InstanceEdit:2162189] Williams, MG, 2012-03-15
crossReference	[DatabaseIdentifier:12667897] RHEA:44564 [DatabaseIdentifier:9855953] RHEA:44565
dbId	2162192
displayName	COQ2 ligates all-E-10PrP2 to PHB
edited	[InstanceEdit:2167908] Williams, MG, 2012-03-23
eventOf	[Pathway:R-HSA-2142789] Ubiquinol biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-2162187] COQ6 hydroxylates DHB - Homo sapiens
input	[SimpleEntity:R-ALL-2162214] all-E-10PrP2 [mitochondrial inner membrane] [SimpleEntity:R-ALL-2162213] PHB [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2162258] Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ [LiteratureReference:2162268] Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells [LiteratureReference:9856238] Missense mutation of the COQ2 gene causes defects of bioenergetics and de novo pyrimidine synthesis
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	COQ2 ligates all-E-10PrP2 to PHB PHB and all-E-10PrP2 are combined into DHB by COQ2
orthologousEvent	[Reaction:R-PFA-2162192] COQ2 ligates all-E-10PrP2 to PHB - Plasmodium falciparum [Reaction:R-SCE-2162192] COQ2 ligates all-E-10PrP2 to PHB - Saccharomyces cerevisiae [Reaction:R-SPO-2162192] COQ2 ligates all-E-10PrP2 to PHB - Schizosaccharomyces pombe [Reaction:R-DDI-2162192] COQ2 ligates all-E-10PrP2 to PHB - Dictyostelium discoideum [Reaction:R-CEL-2162192] COQ2 ligates all-E-10PrP2 to PHB - Caenorhabditis elegans [Reaction:R-DME-2162192] COQ2 ligates all-E-10PrP2 to PHB - Drosophila melanogaster [Reaction:R-GGA-2162192] COQ2 ligates all-E-10PrP2 to PHB - Gallus gallus [Reaction:R-XTR-2162192] COQ2 ligates all-E-10PrP2 to PHB - Xenopus tropicalis [Reaction:R-DRE-2162192] COQ2 ligates all-E-10PrP2 to PHB - Danio rerio [Reaction:R-SSC-2162192] COQ2 ligates all-E-10PrP2 to PHB - Sus scrofa [Reaction:R-BTA-2162192] COQ2 ligates all-E-10PrP2 to PHB - Bos taurus [Reaction:R-CFA-2162192] COQ2 ligates all-E-10PrP2 to PHB - Canis familiaris [Reaction:R-RNO-2162192] COQ2 ligates all-E-10PrP2 to PHB - Rattus norvegicus [Reaction:R-MMU-2162192] COQ2 ligates all-E-10PrP2 to PHB - Mus musculus
output	[SimpleEntity:R-ALL-2162207] DHB [mitochondrial inner membrane] [SimpleEntity:R-ALL-159450] PPi [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-2162253] PDSS1,2 ligates FPP to IPPP - Homo sapiens [Reaction:R-HSA-9856794] Unknown dehydrogenase oxidizes 4-HBz - Homo sapiens
releaseDate	2013-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:3009435] Kawamukai, Makoto, 2013-02-05 [InstanceEdit:9909268] Pierrel, Fabien, 2024-05-02 [InstanceEdit:9909593] Marchi, Marco, 2024-05-14 [InstanceEdit:9910563] Tonello, Fiorella, 2024-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2162192
summation	[Summation:2167900] 4-Hydroxybenzoate polyprenyltransferase (COQ2) catalyses the...
updateTrackers	[UpdateTracker:9864330] Update Tracker - [Reaction:2162192] COQ2 ligates all-E-10PrP2 to PHB - v88:[addLiteratureReference, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9864330] Update Tracker - [Reaction:2162192] COQ2 ligates all-E-10PrP2 to PHB - v88:[addLiteratureReference, modifyText]
(hasEvent)	[Pathway:R-HSA-2142789] Ubiquinol biosynthesis
(precedingEvent)	[Reaction:R-HSA-2162187] COQ6 hydroxylates DHB

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