PHB and all-E-10PrP2 are combined into DHB by COQ2

Stable Identifier
R-HSA-2162192
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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4-hydroxybenzoate polyprenyltransferase, mitochondrial (COQ2) catalyses the combination of 4-hydroxybenzoic acid, aka para-hydroxybenzoic acid (PHB) with the polyisoprenoid tail all-trans-decaprenyl diphosphate (all-E-10PrP2) to form 3-decaprenyl-4-hydroxybenzoic acid (DHB) (Forsgren et a l. 2004, Tekle et al. 2008). This reaction is irreversible and occurs in the mitochondria.

Literature References
PubMed ID Title Journal Year
15153069 Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ

Forsgren, M, Attersand, A, Lake, S, Gr├╝nler, J, Swiezewska, E, Dallner, G, Climent, I

Biochem J 2004
17916383 Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells

Tekle, M, Turunen, M, Dallner, G, Chojnacki, T, Swiezewska, E

J Biochem Biophys Methods 2008
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
4-hydroxybenzoate decaprenyltransferase activity of COQ2 [mitochondrial inner membrane]
Physical Entity
Activity
Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created