Reactome | COQ2 ligates all-E-10PrP2 to PHB

COQ2 ligates all-E-10PrP2 to PHB

Stable Identifier

R-HSA-2162192

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane, mitochondrial matrix

Synonyms

PHB and all-E-10PrP2 are combined into DHB by COQ2

ReviewStatus

5/5

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4-Hydroxybenzoate polyprenyltransferase (COQ2) catalyses the combination of 4-hydroxybenzoic acid, aka para-hydroxybenzoic acid (PHB), with the polyisoprenoid tail all-trans-decaprenyl diphosphate (all-E-10PrP2) to form 3-decaprenyl-4-hydroxybenzoate (DHB) (Forsgren et al., 2004; Lopez-Martin ef al., 2007; Tekle et al., 2008).

Literature References

PubMed ID	Title	Journal	Year
17916383	Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells Dallner, G, Turunen, M, Swiezewska, E, Tekle, M, Chojnacki, T	J Biochem Biophys Methods	2008
17374725	Missense mutation of the COQ2 gene causes defects of bioenergetics and de novo pyrimidine synthesis Salviati, L, Trevisson, E, Sánchez-Alcázar, JA, DiMauro, S, Rodriguez-Hernandez, A, Hirano, M, Quinzii, C, López-Martín, JM, Navas, P, Santos-Ocaña, C, Cordero, MD, Montini, G	Hum Mol Genet	2007
15153069	Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ Dallner, G, Climent, I, Grünler, J, Attersand, A, Swiezewska, E, Forsgren, M, Lake, S	Biochem J	2004