PHB and all-E-10PrP2 are combined into DHB by COQ2

Stable Identifier
R-HSA-2162192
Type
Reaction
Species
Homo sapiens
Compartment
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4-hydroxybenzoate polyprenyltransferase, mitochondrial (COQ2) catalyses the combination of 4-hydroxybenzoic acid, aka para-hydroxybenzoic acid (PHB) with the polyisoprenoid tail all-trans-decaprenyl diphosphate (all-E-10PrP2) to form 3-decaprenyl-4-hydroxybenzoic acid (DHB) (Forsgren et a l. 2004, Tekle et al. 2008). This reaction is irreversible and occurs in the mitochondria.

Literature References
PubMed ID Title Journal Year
17916383 Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells

Dallner, G, Turunen, M, Swiezewska, E, Tekle, M, Chojnacki, T

J Biochem Biophys Methods 2008
15153069 Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ

Dallner, G, Climent, I, Gr├╝nler, J, Attersand, A, Swiezewska, E, Forsgren, M, Lake, S

Biochem J 2004
Participants
Participates
Catalyst Activity

4-hydroxybenzoate decaprenyltransferase activity of COQ2 [mitochondrial inner membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
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