Reactome | PHB and all-E-10PrP2 are combined into DHB by COQ2

PHB and all-E-10PrP2 are combined into DHB by COQ2

Stable Identifier

R-HSA-2162192

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane, mitochondrial matrix

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PHB and all-E-10PrP2 are combined into DHB by COQ2

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4-hydroxybenzoate polyprenyltransferase, mitochondrial (COQ2) catalyses the combination of 4-hydroxybenzoic acid, aka para-hydroxybenzoic acid (PHB) with the polyisoprenoid tail all-trans-decaprenyl diphosphate (all-E-10PrP2) to form 3-decaprenyl-4-hydroxybenzoic acid (DHB) (Forsgren et a l. 2004, Tekle et al. 2008). This reaction is irreversible and occurs in the mitochondria.

Literature References

PubMed ID	Title	Journal	Year
15153069	Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ Forsgren, M, Attersand, A, Lake, S, Grünler, J, Swiezewska, E, Dallner, G, Climent, I	Biochem J	2004
17916383	Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells Tekle, M, Turunen, M, Dallner, G, Chojnacki, T, Swiezewska, E	J Biochem Biophys Methods	2008