Reactome | PHB and all-E-10PrP2 are combined into DHB by COQ2

PHB and all-E-10PrP2 are combined into DHB by COQ2

Stable Identifier

R-HSA-2162192

Type

Reaction [transition]

Species

Homo sapiens

Compartment

mitochondrial inner membrane, mitochondrial matrix

ReviewStatus

5/5

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PHB and all-E-10PrP2 are combined into DHB by COQ2

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4-hydroxybenzoate polyprenyltransferase, mitochondrial (COQ2) catalyses the combination of 4-hydroxybenzoic acid, aka para-hydroxybenzoic acid (PHB) with the polyisoprenoid tail all-trans-decaprenyl diphosphate (all-E-10PrP2) to form 3-decaprenyl-4-hydroxybenzoic acid (DHB) (Forsgren et a l. 2004, Tekle et al. 2008). This reaction is irreversible and occurs in the mitochondria.

Literature References

PubMed ID	Title	Journal	Year
17916383	Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells Dallner, G, Turunen, M, Swiezewska, E, Tekle, M, Chojnacki, T	J Biochem Biophys Methods	2008
15153069	Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ Dallner, G, Climent, I, Grünler, J, Attersand, A, Swiezewska, E, Forsgren, M, Lake, S	Biochem J	2004