PHB and all-E-10PrP2 are combined into DHB by COQ2

Stable Identifier
R-HSA-2162192
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

4-hydroxybenzoate polyprenyltransferase, mitochondrial (COQ2) catalyses the combination of 4-hydroxybenzoic acid, aka para-hydroxybenzoic acid (PHB) with the polyisoprenoid tail all-trans-decaprenyl diphosphate (all-E-10PrP2) to form 3-decaprenyl-4-hydroxybenzoic acid (DHB) (Forsgren et a l. 2004, Tekle et al. 2008). This reaction is irreversible and occurs in the mitochondria.

Literature References
PubMed ID Title Journal Year
17916383 Investigation of coenzyme Q biosynthesis in human fibroblast and HepG2 cells

Dallner, G, Turunen, M, Swiezewska, E, Tekle, M, Chojnacki, T

J Biochem Biophys Methods 2008
15153069 Isolation and functional expression of human COQ2, a gene encoding a polyprenyl transferase involved in the synthesis of CoQ

Dallner, G, Climent, I, Grünler, J, Attersand, A, Swiezewska, E, Forsgren, M, Lake, S

Biochem J 2004
Participants
Participates
Catalyst Activity

4-hydroxybenzoate decaprenyltransferase activity of COQ2 [mitochondrial inner membrane]

Orthologous Events
Cross References
Rhea
Authored
Reviewed
Created
Cite Us!