Reactome | carbovir + IMP => carbovir monophosphate + inosine

Schema > Reaction > Entries

carbovir + IMP => carbovir monophosphate + inosine Show undefined attributes

authored	[InstanceEdit:2162171] D'Eustachio, P, 2012-03-14
catalystActivity	[CatalystActivity:2161536] nucleoside phosphotransferase activity of NT5C2 tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2162100] D'Eustachio, P, 2012-03-14
dbId	2162066
displayName	carbovir + IMP => carbovir monophosphate + inosine
edited	[InstanceEdit:2162250] D'Eustachio, P, 2012-03-16
eventOf	[Pathway:R-HSA-2161541] Abacavir metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-2162092] carbovir monophosphate + ATP => carbovir diphosphate + ADP - Homo sapiens
input	[ChemicalDrug:R-ALL-2161514] carbovir [cytosol] [SimpleEntity:R-ALL-29602] IMP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2161513] Phosphorylation of 2',3'-dideoxyinosine by cytosolic 5'-nucleotidase of human lymphoid cells [LiteratureReference:2161101] Phosphorylation of carbovir enantiomers by cellular enzymes determines the stereoselectivity of antiviral activity [LiteratureReference:109314] High Km soluble 5'-nucleotidase from human placenta [LiteratureReference:500117] Crystal structure of human cytosolic 5'-nucleotidase II: insights into allosteric regulation and substrate recognition
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	carbovir + IMP => carbovir monophosphate + inosine Conversion of carbovir to carbovir monophosphate
orthologousEvent	[Reaction:R-DDI-2162066] carbovir + IMP => carbovir monophosphate + inosine - Dictyostelium discoideum [Reaction:R-CEL-2162066] carbovir + IMP => carbovir monophosphate + inosine - Caenorhabditis elegans [Reaction:R-DME-2162066] carbovir + IMP => carbovir monophosphate + inosine - Drosophila melanogaster [Reaction:R-GGA-2162066] carbovir + IMP => carbovir monophosphate + inosine - Gallus gallus [Reaction:R-XTR-2162066] carbovir + IMP => carbovir monophosphate + inosine - Xenopus tropicalis [Reaction:R-SSC-2162066] carbovir + IMP => carbovir monophosphate + inosine - Sus scrofa [Reaction:R-BTA-2162066] carbovir + IMP => carbovir monophosphate + inosine - Bos taurus [Reaction:R-CFA-2162066] carbovir + IMP => carbovir monophosphate + inosine - Canis familiaris [Reaction:R-RNO-2162066] carbovir + IMP => carbovir monophosphate + inosine - Rattus norvegicus [Reaction:R-MMU-2162066] carbovir + IMP => carbovir monophosphate + inosine - Mus musculus
output	[ChemicalDrug:R-ALL-2161176] carbovir monophosphate [cytosol] [SimpleEntity:R-ALL-83927] Ino [cytosol]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2162241] Jassal, B, 2012-03-16
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2162066
summation	[Summation:2162065] NT5C2 catalyzes the reaction of carbovir and IMP to form car...

Referrals

(hasEvent)	[Pathway:R-HSA-2161541] Abacavir metabolism
(precedingEvent)	[Reaction:R-HSA-2162092] carbovir monophosphate + ATP => carbovir diphosphate + ADP