Reactome | LTB4 is oxidised to 12-oxoLTB4 by PTGR1

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LTB4 is oxidised to 12-oxoLTB4 by PTGR1 Show undefined attributes

authored	[InstanceEdit:2142839] Williams, MG, 2012-02-24
catalystActivity	[CatalystActivity:2161632] leukotriene B4 12-hydroxy dehydrogenase activity of PTGR1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:2161624] Williams, MG, 2012-03-14
crossReference	[DatabaseIdentifier:12668395] RHEA:50609 [DatabaseIdentifier:9915864] RHEA:50609
dbId	2161567
displayName	LTB4 is oxidised to 12-oxoLTB4 by PTGR1
edited	[InstanceEdit:2142839] Williams, MG, 2012-02-24
eventOf	[Pathway:R-HSA-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX) - Homo sapiens
inferredFrom	[Reaction:R-SSC-2161617] LTB4 is oxidised to 12-oxoLTB4 by PTGR1 - Sus scrofa
input	[SimpleEntity:R-ALL-266056] LTB4 [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:2161669] cDNA cloning, expression, and mutagenesis study of leukotriene B4 12-hydroxydehydrogenase [LiteratureReference:2161719] Enzymatic inactivation of leukotriene B4 by a novel enzyme found in the porcine kidney. Purification and properties of leukotriene B4 12-hydroxydehydrogenase [LiteratureReference:2161703] Purification, cDNA cloning and expression of 15-oxoprostaglandin 13-reductase from pig lung
maxDepth	1
modified	[InstanceEdit:9915866] D'Eustachio, Peter, 2024-07-17
name	LTB4 is oxidised to 12-oxoLTB4 by PTGR1 leukotriene B4 + NADP(+) => 12-oxo-leukotriene B4 + H(+) + NADPH
output	[SimpleEntity:R-ALL-2142810] 12-oxoLTB4 [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
precedingEvent	[Reaction:R-HSA-266072] LTA4 is hydolysed to LTB4 by LTA4H - Homo sapiens
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2569042] Rush, MG, 2012-11-10
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2161567
summation	[Summation:2161633] Prostaglandin reductase 1 (PTGR1) aka LTB4DH metabolizes eic...

Referrals

(hasEvent)	[Pathway:R-HSA-2142691] Synthesis of Leukotrienes (LT) and Eoxins (EX)
(inferredTo)	[Reaction:R-SSC-2161617] LTB4 is oxidised to 12-oxoLTB4 by PTGR1

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