Reactome | MHC class II antigen processing

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MHC class II antigen processing Show undefined attributes

authored	[InstanceEdit:2132294] Garapati, P V, 2012-02-21
catalystActivity	[CatalystActivity:2130638] cysteine-type endopeptidase activity of Cathepsin [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:2130630] Garapati, P V, 2012-02-21
dbId	2130706
displayName	MHC class II antigen processing
edited	[InstanceEdit:2132294] Garapati, P V, 2012-02-21
eventOf	[Pathway:R-HSA-2132295] MHC class II antigen presentation - Homo sapiens
followingEvent	[Reaction:R-HSA-2213244] Loading of antigenic peptides - Homo sapiens
input	[OtherEntity:R-ALL-2213225] unfolded antigen [lysosomal lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2213080] Asparaginyl endopeptidase: case history of a class II MHC compartment protease [LiteratureReference:2213129] Antigen processing and presentation in human muscle: cathepsin S is critical for MHC class II expression and upregulated in inflammatory myopathies [LiteratureReference:2213070] Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation [LiteratureReference:2213112] Lysosomal cathepsin B plays an important role in antigen processing, while cathepsin D is involved in degradation of the invariant chain inovalbumin-immunized mice [LiteratureReference:2213157] Specific role for cathepsin S in the generation of antigenic peptides in vivo
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	MHC class II antigen processing
orthologousEvent	[Reaction:R-PFA-2130706] MHC class II antigen processing - Plasmodium falciparum [Reaction:R-SCE-2130706] MHC class II antigen processing - Saccharomyces cerevisiae [Reaction:R-SPO-2130706] MHC class II antigen processing - Schizosaccharomyces pombe [Reaction:R-DDI-2130706] MHC class II antigen processing - Dictyostelium discoideum [Reaction:R-CEL-2130706] MHC class II antigen processing - Caenorhabditis elegans [Reaction:R-DME-2130706] MHC class II antigen processing - Drosophila melanogaster [Reaction:R-GGA-2130706] MHC class II antigen processing - Gallus gallus [Reaction:R-XTR-2130706] MHC class II antigen processing - Xenopus tropicalis [Reaction:R-DRE-2130706] MHC class II antigen processing - Danio rerio [Reaction:R-SSC-2130706] MHC class II antigen processing - Sus scrofa [Reaction:R-BTA-2130706] MHC class II antigen processing - Bos taurus [Reaction:R-CFA-2130706] MHC class II antigen processing - Canis familiaris [Reaction:R-RNO-2130706] MHC class II antigen processing - Rattus norvegicus [Reaction:R-MMU-2130706] MHC class II antigen processing - Mus musculus
output	3 × [OtherEntity:R-ALL-2213226] MHC class II epitopes [lysosomal lumen]
precedingEvent	[Reaction:R-HSA-2213240] Reduction of disulphide bonds in MHC II antigens - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2247930] Neefjes, Jacques, 2012-05-14
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2130706
summation	[Summation:2130494] Antigen processing and loading on to MHC class II molecules ...
updateTrackers	[UpdateTracker:9984731] Update Tracker - [Reaction:2130706] MHC class II antigen processing - v96:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9984731] Update Tracker - [Reaction:2130706] MHC class II antigen processing - v96:[modifyText]
(hasEvent)	[Pathway:R-HSA-2132295] MHC class II antigen presentation
(precedingEvent)	[Reaction:R-HSA-2213244] Loading of antigenic peptides

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