Reactome | MHC class II antigen processing

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MHC class II antigen processing Show undefined attributes

catalystActivity	[CatalystActivity:10601395] cysteine-type endopeptidase activity of Cathepsin [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:10559787] Weiser, Joel, 2026-03-16
dbId	10602261
displayName	MHC class II antigen processing
eventOf	[Pathway:R-DRE-2132295] MHC class II antigen presentation - Danio rerio
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-DRE-2213244] Loading of antigenic peptides - Danio rerio
inferredFrom	[Reaction:R-HSA-2130706] MHC class II antigen processing - Homo sapiens
input	[OtherEntity:R-ALL-2213225] unfolded antigen [lysosomal lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	MHC class II antigen processing
output	3 × [OtherEntity:R-ALL-2213226] MHC class II epitopes [lysosomal lumen]
precedingEvent	[Reaction:R-DRE-2213240] Reduction of disulphide bonds in MHC II antigens - Danio rerio
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68323] Danio rerio
stId	R-DRE-2130706
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DRE-2132295] MHC class II antigen presentation
(precedingEvent)	[Reaction:R-DRE-2213244] Loading of antigenic peptides
(inferredTo)	[Reaction:R-HSA-2130706] MHC class II antigen processing

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