Reactome | Fibrillin C-terminal processing

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Fibrillin C-terminal processing Show undefined attributes

authored	[InstanceEdit:2214334] Jupe, S, 2012-04-30
catalystActivity	[CatalystActivity:2159870] serine-type endopeptidase activity of FURIN [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2129374] Jupe, S, 2012-02-21
dbId	2129357
displayName	Fibrillin C-terminal processing
edited	[InstanceEdit:2580335] Jupe, S, 2012-11-12
eventOf	[Pathway:R-HSA-1566948] Elastic fibre formation - Homo sapiens
followingEvent	[Polymerisation:R-HSA-2129362] Fibrillin microfibril assembly - Homo sapiens
input	[CandidateSet:R-HSA-2159860] Profibrillins [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2129364] Carboxy-terminal conversion of profibrillin to fibrillin at a basic site by PACE/furin-like activity required for incorporation in the matrix
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Fibrillin C-terminal processing
orthologousEvent	[Reaction:R-CEL-2129357] Fibrillin C-terminal processing - Caenorhabditis elegans [Reaction:R-GGA-2129357] Fibrillin C-terminal processing - Gallus gallus [Reaction:R-DRE-2129357] Fibrillin C-terminal processing - Danio rerio [Reaction:R-SSC-2129357] Fibrillin C-terminal processing - Sus scrofa [Reaction:R-BTA-2129357] Fibrillin C-terminal processing - Bos taurus [Reaction:R-CFA-2129357] Fibrillin C-terminal processing - Canis familiaris [Reaction:R-RNO-2129357] Fibrillin C-terminal processing - Rattus norvegicus [Reaction:R-MMU-2129357] Fibrillin C-terminal processing - Mus musculus
output	[CandidateSet:R-HSA-2159858] Fibrillin C-term fragments [extracellular region] [CandidateSet:R-HSA-2159821] Fibrillin peptides [extracellular region]
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2550420] Muiznieks, Lisa, 2012-11-02
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2129357
summation	[Summation:2129382] Extracellular deposition of fibrillin requires removal of th...

Referrals

(hasEvent)	[Pathway:R-HSA-1566948] Elastic fibre formation
(precedingEvent)	[Polymerisation:R-HSA-2129362] Fibrillin microfibril assembly

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