Reactome | CYP4F8 19-hydroxylates PGH2

Schema > Reaction > Entries

CYP4F8 19-hydroxylates PGH2 Show undefined attributes

authored	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
catalystActivity	[CatalystActivity:215524] monooxygenase activity of Cytochrome P450 (CYP4F8 based) [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17960] smooth endoplasmic reticulum
created	[InstanceEdit:211969] Jassal, B, 2008-02-08 15:33:52
dbId	211919
displayName	CYP4F8 19-hydroxylates PGH2
edited	[InstanceEdit:350358] Jassal, Bijay, 2008-05-19
eventOf	[Pathway:R-HSA-211979] Eicosanoids - Homo sapiens
input	[SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113601] NADPH [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-30138] PGH2 [endoplasmic reticulum lumen]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:215520] Identification of CYP4F8 in human seminal vesicles as a prominent 19-hydroxylase of prostaglandin endoperoxides [LiteratureReference:215537] Gene expression of a novel cytochrome P450 of the CYP4F subfamily in human seminal vesicles
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	CYP4F8 19-hydroxylates PGH2
orthologousEvent	[Reaction:R-DME-211919] CYP4F8 19-hydroxylates PGH2 - Drosophila melanogaster [Reaction:R-GGA-211919] CYP4F8 19-hydroxylates PGH2 - Gallus gallus [Reaction:R-XTR-211919] CYP4F8 19-hydroxylates PGH2 - Xenopus tropicalis [Reaction:R-DRE-211919] CYP4F8 19-hydroxylates PGH2 - Danio rerio [Reaction:R-SSC-211919] CYP4F8 19-hydroxylates PGH2 - Sus scrofa [Reaction:R-BTA-211919] CYP4F8 19-hydroxylates PGH2 - Bos taurus [Reaction:R-CFA-211919] CYP4F8 19-hydroxylates PGH2 - Canis familiaris [Reaction:R-RNO-211919] CYP4F8 19-hydroxylates PGH2 - Rattus norvegicus [Reaction:R-MMU-211919] CYP4F8 19-hydroxylates PGH2 - Mus musculus
output	[SimpleEntity:R-ALL-215545] 19OH-PGH2 [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113564] NADP+ [endoplasmic reticulum lumen]
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
revised	[InstanceEdit:5602271] Jassal, Bijay, 2014-06-23
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-211919
summation	[Summation:215541] 19-hydroxyprostaglandins E1 and E2 (19OH-PGE1 and 2) are maj...
updateTrackers	[UpdateTracker:9785992] Update Tracker - [Reaction:211919] CYP4F8 19-hydroxylates PGH2 - v50:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9785992] Update Tracker - [Reaction:211919] CYP4F8 19-hydroxylates PGH2 - v50:[modifyText]
(hasEvent)	[Pathway:R-HSA-211979] Eicosanoids