Reactome | Tyrosine is diiodinated

Schema > Reaction > Entries

Tyrosine is diiodinated Show undefined attributes

authored	[InstanceEdit:378946] Jassal, Bijay, 2008-10-01
catalystActivity	[CatalystActivity:209956] halogenase activity of p-DUOX1,2:DUOXA1,2:TPO:CAV1:TXNDC11 [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:209970] Jassal, Bijay, 2008-01-08
dbId	209973
displayName	Tyrosine is diiodinated
edited	[InstanceEdit:209970] Jassal, Bijay, 2008-01-08
eventOf	[Pathway:R-HSA-209968] Thyroxine biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-209925] DIT and MIT combine to form triiodothyronine - Homo sapiens [Reaction:R-HSA-209840] Two DITs combine to form thyroxine - Homo sapiens [Reaction:R-HSA-209960] Diiodinated tyrosine can be deiodinated - Homo sapiens
input	[SimpleEntity:R-ALL-351626] H+ [extracellular region] [SimpleEntity:R-ALL-351629] H2O2 [extracellular region] 2 × [SimpleEntity:R-ALL-209818] I- [extracellular region] [SimpleEntity:R-ALL-352030] L-Tyr [extracellular region] [SimpleEntity:R-ALL-351627] NADPH [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:350844] Biosynthesis of thyroid hormone: basic and clinical aspects
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Tyrosine is diiodinated
orthologousEvent	[Reaction:R-RNO-209973] Tyrosine is diiodinated - Rattus norvegicus [Reaction:R-CEL-209973] Tyrosine is diiodinated - Caenorhabditis elegans [Reaction:R-DME-209973] Tyrosine is diiodinated - Drosophila melanogaster [Reaction:R-GGA-209973] Tyrosine is diiodinated - Gallus gallus [Reaction:R-XTR-209973] Tyrosine is diiodinated - Xenopus tropicalis [Reaction:R-SSC-209973] Tyrosine is diiodinated - Sus scrofa [Reaction:R-BTA-209973] Tyrosine is diiodinated - Bos taurus [Reaction:R-CFA-209973] Tyrosine is diiodinated - Canis familiaris [Reaction:R-MMU-209973] Tyrosine is diiodinated - Mus musculus
output	[SimpleEntity:R-ALL-352329] DIT [extracellular region] 2 × [SimpleEntity:R-ALL-109276] H2O [extracellular region] [SimpleEntity:R-ALL-351628] NADP+ [extracellular region]
precedingEvent	[Reaction:R-HSA-209960] Diiodinated tyrosine can be deiodinated - Homo sapiens [Reaction:R-HSA-350901] Iodide is organified - Homo sapiens
releaseDate	2008-06-30
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-209973
summation	[Summation:352328] Thyroid peroxidase (TPO) catalyzes the iodination of iodotyr...
updateTrackers	[UpdateTracker:9790766] Update Tracker - [Reaction:209973] Tyrosine is diiodinated - v33:[add_removeInput] [UpdateTracker:9971932] Update Tracker - [Reaction:209973] Tyrosine is diiodinated - v95:[modifyText] [UpdateTracker:9964717] Update Tracker - [Reaction:209973] Tyrosine is diiodinated - v94:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9790766] Update Tracker - [Reaction:209973] Tyrosine is diiodinated - v33:[add_removeInput] [UpdateTracker:9971932] Update Tracker - [Reaction:209973] Tyrosine is diiodinated - v95:[modifyText] [UpdateTracker:9964717] Update Tracker - [Reaction:209973] Tyrosine is diiodinated - v94:[modifyText]
(hasEvent)	[Pathway:R-HSA-209968] Thyroxine biosynthesis
(precedingEvent)	[Reaction:R-HSA-209925] DIT and MIT combine to form triiodothyronine [Reaction:R-HSA-209840] Two DITs combine to form thyroxine [Reaction:R-HSA-209960] Diiodinated tyrosine can be deiodinated

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