Reactome | Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA

Schema > Reaction > Entries

Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA Show undefined attributes

authored	[InstanceEdit:2046103] Garapati, P V, 2012-01-11
catalystActivity	[CatalystActivity:2046082] acyl-CoA 6-desaturase activity of FADS2 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:2046086] Garapati, P V, 2012-01-11
dbId	2046096
displayName	Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA
edited	[InstanceEdit:2046103] Garapati, P V, 2012-01-11
eventOf	[Pathway:R-HSA-2046105] Linoleic acid (LA) metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-2046094] Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA - Homo sapiens
input	[SimpleEntity:R-ALL-2046063] LA-CoA [endoplasmic reticulum lumen] 2 × [SimpleEntity:R-ALL-194697] NADH [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:2046034] Identification of the delta-6 desaturase of human sebaceous glands: expression and enzyme activity [LiteratureReference:2045986] Regulation of human delta-6 desaturase gene transcription: identification of a functional direct repeat-1 element [LiteratureReference:2045982] The same rat Delta6-desaturase not only acts on 18- but also on 24-carbon fatty acids in very-long-chain polyunsaturated fatty acid biosynthesis
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA
orthologousEvent	[Reaction:R-CEL-2046096] Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA - Caenorhabditis elegans [Reaction:R-GGA-2046096] Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA - Gallus gallus [Reaction:R-DRE-2046096] Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA - Danio rerio [Reaction:R-SSC-2046096] Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA - Sus scrofa [Reaction:R-BTA-2046096] Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA - Bos taurus [Reaction:R-CFA-2046096] Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA - Canis familiaris [Reaction:R-RNO-2046096] Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA - Rattus norvegicus [Reaction:R-MMU-2046096] Desaturation of Linoleoyl-CoA to gamma-linolenoyl-CoA - Mus musculus
output	[SimpleEntity:R-ALL-2046042] GLA-CoA [endoplasmic reticulum lumen] 2 × [SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] 2 × [SimpleEntity:R-ALL-194653] NAD+ [endoplasmic reticulum lumen]
precedingEvent	[Reaction:R-HSA-2046098] Activation of linoleic acid to linoleoyl-CoA - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2046096
summation	[Summation:2045931] The first major step in the metabolism of linoleic acid (LA)...

Referrals

(hasEvent)	[Pathway:R-HSA-2046105] Linoleic acid (LA) metabolism
(precedingEvent)	[Reaction:R-HSA-2046094] Elongation of gamma-lenolenoyl-CoA to dihomo-gamma-lenolenoyl-CoA