The first major step in the metabolism of linoleic acid (LA)...

created [InstanceEdit:2045929] Garapati, P V, 2012-01-11
dbId 2045931
displayName The first major step in the metabolism of linoleic acid (LA)...
literatureReference
modified [InstanceEdit:2076702] Jupe, S, 2012-01-27
schemaClass Summation
text The first major step in the metabolism of linoleic acid (LA) is desaturation of delta 9,12-octadecadienoyl CoA/linoleoyl CoA (LA-CoA) to delta 6,9,12-octodecatrienoyl CoA/gamma-lenoleoyl CoA (GLA-CoA). This step is catalyzed by delta-6-destaurase (fatty acid desaturase-2, FADS2) which introduces a cis-double bond between carbons 6 and 7. This is the rate limiting step in LA metabolism (Horrobin 1993).
Cite Us!