Reactome | FGFR2b mutants with enhanced ligand binding [plasma membrane]

Schema > DefinedSet > Entries

compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-HSA-2033474] FGFR2b mutants bind an expanded range of ligands - Homo sapiens [Reaction:R-HSA-2033474] FGFR2b mutants bind an expanded range of ligands - Homo sapiens
created	[InstanceEdit:2033372] Rothfels, K, 2012-01-09
crossReference	[DatabaseIdentifier:12020831] Mondo:0019796
dbId	2033371
disease	[Disease:1500689] cancer [Disease:1614674] female reproductive endometrioid cancer [Disease:1500575] ovarian cancer [Disease:2011822] acrocephalosyndactylia [Disease:2032940] bone development disease
displayName	FGFR2b mutants with enhanced ligand binding [plasma membrane]
hasMember	[EntityWithAccessionedSequence:R-HSA-2011846] FGFR2b S252W [plasma membrane] - Homo sapiens [EntityWithAccessionedSequence:R-HSA-2011851] FGFR2b P253R [plasma membrane] - Homo sapiens
inDisease	true
maxDepth	2
modified	[InstanceEdit:2065859] Rothfels, K, 2012-01-24
name	FGFR2b mutants with enhanced ligand binding
schemaClass	DefinedSet
species	[Species:48887] Homo sapiens
stId	R-HSA-2033371

(input)	[Reaction:R-HSA-2033474] FGFR2b mutants bind an expanded range of ligands
(diseaseEntity)	[EntityFunctionalStatus:5654518] gain_of_function of FGFR2b mutants with enhanced ligand binding [plasma membrane]

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