Reactome | p-6Y-FGFR3 K650T [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

p-6Y-FGFR3 K650T [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-2033326] Activated FGFR3 K650T mutant [plasma membrane] - Homo sapiens [Complex:R-HSA-2033326] Activated FGFR3 K650T mutant [plasma membrane] - Homo sapiens
created	[InstanceEdit:2032965] Rothfels, K, 2012-01-08
crossReference	[DatabaseIdentifier:12021292] Mondo:0005447 [DatabaseIdentifier:2032967] COSMIC:COSV53394867
dbId	2032966
disease	[Disease:1493885] bladder carcinoma [Disease:2032940] bone development disease [Disease:1500689] cancer [Disease:1625207] hypochondroplasia [Disease:2032943] testicular cancer
displayName	p-6Y-FGFR3 K650T [plasma membrane]
endCoordinate	806
hasModifiedResidue	[ModifiedResidue:2032947] O4'-phospho-L-tyrosine at unknown position [ModifiedResidue:2032947] O4'-phospho-L-tyrosine at unknown position [ModifiedResidue:2032947] O4'-phospho-L-tyrosine at unknown position [ModifiedResidue:2032947] O4'-phospho-L-tyrosine at unknown position [ModifiedResidue:2032947] O4'-phospho-L-tyrosine at unknown position [ModifiedResidue:2032947] O4'-phospho-L-tyrosine at unknown position [ReplacedResidue:1614413] L-lysine 650 replaced with L-threonine
inDisease	true
literatureReference	[LiteratureReference:2032927] Distinct missense mutations of the FGFR3 lys650 codon modulate receptor kinase activation and the severity of the skeletal dysplasia phenotype [LiteratureReference:1637853] Novel fibroblast growth factor receptor 3 (FGFR3) mutations in bladder cancer previously identified in non-lethal skeletal disorders [LiteratureReference:2032919] Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors
maxDepth	1
modified	[InstanceEdit:9767532] Rothfels, Karen, 2022-02-28
name	p-6Y-FGFR3 K650T
referenceEntity	[ReferenceGeneProduct:uniprot:P22607] UniProt:P22607 FGFR3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-2032966
startCoordinate	23
updateTrackers	[UpdateTracker:9890060] Update Tracker - [EntityWithAccessionedSequence:2032966] p-6Y-FGFR3 K650T [plasma membrane] - v52:[modifyName] [UpdateTracker:9903728] Update Tracker - [EntityWithAccessionedSequence:2032966] p-6Y-FGFR3 K650T [plasma membrane] - v80:[addHasModifiedResidue]

Referrals

(updatedInstance)	[UpdateTracker:9890060] Update Tracker - [EntityWithAccessionedSequence:2032966] p-6Y-FGFR3 K650T [plasma membrane] - v52:[modifyName] [UpdateTracker:9903728] Update Tracker - [EntityWithAccessionedSequence:2032966] p-6Y-FGFR3 K650T [plasma membrane] - v80:[addHasModifiedResidue]
(hasComponent)	[Complex:R-HSA-2033326] Activated FGFR3 K650T mutant [plasma membrane]