Reactome | p-6Y-FGFR3 K650N [plasma membrane]

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p-6Y-FGFR3 K650N [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-2033380] Activated FGFR3 K650N mutant [plasma membrane] - Homo sapiens
created	[InstanceEdit:2032960] Rothfels, K, 2012-01-08
dbId	2032961
disease	[Disease:1500689] cancer [Disease:2032943] testicular cancer [Disease:2032940] bone development disease [Disease:1625207] hypochondroplasia
displayName	p-6Y-FGFR3 K650N [plasma membrane]
endCoordinate	806
hasModifiedResidue	[ModifiedResidue:2032947] O4'-phospho-L-tyrosine at unknown position [ModifiedResidue:2032947] O4'-phospho-L-tyrosine at unknown position [ModifiedResidue:2032947] O4'-phospho-L-tyrosine at unknown position [ModifiedResidue:2032947] O4'-phospho-L-tyrosine at unknown position [ModifiedResidue:2032947] O4'-phospho-L-tyrosine at unknown position [ModifiedResidue:2032947] O4'-phospho-L-tyrosine at unknown position [ReplacedResidue:1614407] L-lysine 650 replaced with L-asparagine
inDisease	true
literatureReference	[LiteratureReference:2032927] Distinct missense mutations of the FGFR3 lys650 codon modulate receptor kinase activation and the severity of the skeletal dysplasia phenotype [LiteratureReference:2032919] Activating mutations in FGFR3 and HRAS reveal a shared genetic origin for congenital disorders and testicular tumors
modified	[InstanceEdit:5649597] Rothfels, Karen, 2014-11-20
name	p-6Y-FGFR3 K650N
referenceEntity	[ReferenceGeneProduct:403340] UniProt:P22607 FGFR3
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-2032961
startCoordinate	23

Referrals

(hasComponent)

[Complex:R-HSA-2033380] Activated FGFR3 K650N mutant [plasma membrane]

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