Reactome | p-8Y-FGFR2b S373C [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

p-8Y-FGFR2b S373C [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-2029906] Activated FGFR2b S373C mutant [plasma membrane] - Homo sapiens [Complex:R-HSA-2029906] Activated FGFR2b S373C mutant [plasma membrane] - Homo sapiens
created	[InstanceEdit:2029868] Rothfels, K, 2012-01-05
crossReference	[DatabaseIdentifier:12020811] Mondo:0002480
dbId	2029869
disease	[Disease:1614674] female reproductive endometrioid cancer
displayName	p-8Y-FGFR2b S373C [plasma membrane]
endCoordinate	822
hasModifiedResidue	[ModifiedResidue:190945] O4'-phospho-L-tyrosine at 467 [ModifiedResidue:190951] O4'-phospho-L-tyrosine at 587 [ModifiedResidue:190950] O4'-phospho-L-tyrosine at 589 [ModifiedResidue:190947] O4'-phospho-L-tyrosine at 657 [ModifiedResidue:190409] O4'-phospho-L-tyrosine at 658 [ModifiedResidue:190948] O4'-phospho-L-tyrosine at 734 [ModifiedResidue:190949] O4'-phospho-L-tyrosine at 770 [ModifiedResidue:1307909] O4'-phospho-L-tyrosine at 780 [ReplacedResidue:1637926] L-serine 373 replaced with L-cysteine
inDisease	true
literatureReference	[LiteratureReference:1637882] Drug-sensitive FGFR2 mutations in endometrial carcinoma [LiteratureReference:2011820] Proline to arginine mutations in FGF receptors 1 and 3 result in Pfeiffer and Muenke craniosynostosis syndromes through enhancement of FGF binding affinity [LiteratureReference:1637876] Apert syndrome results from localized mutations of FGFR2 and is allelic with Crouzon syndrome
maxDepth	1
modified	[InstanceEdit:5649616] Rothfels, Karen, 2014-11-20
name	p-8Y-FGFR2b S373C p-8Y-FGFR2-3 S373C
referenceEntity	[ReferenceIsoform:uniprot:P21802-3] UniProt:P21802-3 FGFR2
referenceType	ReferenceIsoform
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-2029869
startCoordinate	22
summation	[Summation:1637914] also Apert
updateTrackers	[UpdateTracker:9891037] Update Tracker - [EntityWithAccessionedSequence:2029869] p-8Y-FGFR2b S373C [plasma membrane] - v52:[modifyName] [UpdateTracker:9885865] Update Tracker - [EntityWithAccessionedSequence:2029869] p-8Y-FGFR2b S373C [plasma membrane] - v45:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9891037] Update Tracker - [EntityWithAccessionedSequence:2029869] p-8Y-FGFR2b S373C [plasma membrane] - v52:[modifyName] [UpdateTracker:9885865] Update Tracker - [EntityWithAccessionedSequence:2029869] p-8Y-FGFR2b S373C [plasma membrane] - v45:[modifyName]
(hasComponent)	[Complex:R-HSA-2029906] Activated FGFR2b S373C mutant [plasma membrane]