Reactome | p-8Y-FGFR2b S376C [plasma membrane]

Schema > EntityWithAccessionedSequence > Entries

p-8Y-FGFR2b S376C [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-2029909] Activated FGFR2b S376C mutant [plasma membrane] - Homo sapiens [Complex:R-HSA-2029909] Activated FGFR2b S376C mutant [plasma membrane] - Homo sapiens
created	[InstanceEdit:2029867] Rothfels, K, 2012-01-05
crossReference	[DatabaseIdentifier:12020811] Mondo:0002480
dbId	2029866
disease	[Disease:1614674] female reproductive endometrioid cancer [Disease:1500575] ovarian cancer
displayName	p-8Y-FGFR2b S376C [plasma membrane]
endCoordinate	822
hasModifiedResidue	[ModifiedResidue:190945] O4'-phospho-L-tyrosine at 467 [ModifiedResidue:190951] O4'-phospho-L-tyrosine at 587 [ModifiedResidue:190950] O4'-phospho-L-tyrosine at 589 [ModifiedResidue:190947] O4'-phospho-L-tyrosine at 657 [ModifiedResidue:190409] O4'-phospho-L-tyrosine at 658 [ModifiedResidue:190948] O4'-phospho-L-tyrosine at 734 [ModifiedResidue:190949] O4'-phospho-L-tyrosine at 770 [ModifiedResidue:1307909] O4'-phospho-L-tyrosine at 780 [ReplacedResidue:1637932] L-tyrosine 376 replaced with L-cysteine
inDisease	true
literatureReference	[LiteratureReference:1637882] Drug-sensitive FGFR2 mutations in endometrial carcinoma [LiteratureReference:2029807] FGFR2 mutations are rare across histologic subtypes of ovarian cancer [LiteratureReference:1637891] Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes [LiteratureReference:1614274] Targeting mutant fibroblast growth factor receptors in cancer
maxDepth	1
modified	[InstanceEdit:5649617] Rothfels, Karen, 2014-11-20
name	p-8Y-FGFR2b S376C p-8Y-FGFR2-3 S376C
referenceEntity	[ReferenceIsoform:uniprot:P21802-3] UniProt:P21802-3 FGFR2
referenceType	ReferenceIsoform
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-2029866
startCoordinate	22
summation	[Summation:1637914] also Apert
updateTrackers	[UpdateTracker:9882583] Update Tracker - [EntityWithAccessionedSequence:2029866] p-8Y-FGFR2b S376C [plasma membrane] - v45:[modifyName] [UpdateTracker:9890165] Update Tracker - [EntityWithAccessionedSequence:2029866] p-8Y-FGFR2b S376C [plasma membrane] - v52:[modifyName]

Referrals

(updatedInstance)	[UpdateTracker:9882583] Update Tracker - [EntityWithAccessionedSequence:2029866] p-8Y-FGFR2b S376C [plasma membrane] - v45:[modifyName] [UpdateTracker:9890165] Update Tracker - [EntityWithAccessionedSequence:2029866] p-8Y-FGFR2b S376C [plasma membrane] - v52:[modifyName]
(hasComponent)	[Complex:R-HSA-2029909] Activated FGFR2b S376C mutant [plasma membrane]