Reactome | Integrin alpha5beta1 binds FN1 dimer

Schema > Reaction > Entries

Integrin alpha5beta1 binds FN1 dimer Show undefined attributes

authored	[InstanceEdit:203275] Ouwehand, W.H., 2007-11-12 16:45:54
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:202725] de Bono, B, 2007-11-11 16:10:42
dbId	202723
displayName	Integrin alpha5beta1 binds FN1 dimer
edited	[InstanceEdit:453306] Jupe, S, 2010-01-21
eventOf	[Pathway:R-HSA-1566977] Fibronectin matrix formation - Homo sapiens [Pathway:R-HSA-202733] Cell surface interactions at the vascular wall - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-2327746] FN1 aggregation - Homo sapiens
input	[Complex:R-HSA-266103] FN1 dimer [extracellular region] [Complex:R-HSA-202730] Integrin alpha5beta1 [plasma membrane] [SimpleEntity:R-ALL-266099] Mn2+ [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:202729] beta 1 integrin function in vivo: adhesion, migration and more [LiteratureReference:203265] The alpha v beta 1 integrin functions as a fibronectin receptor but does not support fibronectin matrix assembly and cell migration on fibronectin [LiteratureReference:202737] GPI-anchored CEA family glycoproteins CEA and CEACAM6 mediate their biological effects through enhanced integrin alpha5beta1-fibronectin interaction [LiteratureReference:216910] Integrin alpha8beta1-fibronectin interactions promote cell survival via PI3 kinase pathway
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	Integrin alpha5beta1 binds FN1 dimer
orthologousEvent	[Reaction:R-CEL-202723] Integrin alpha5beta1 binds FN1 dimer - Caenorhabditis elegans [Reaction:R-GGA-202723] Integrin alpha5beta1 binds FN1 dimer - Gallus gallus [Reaction:R-XTR-202723] Integrin alpha5beta1 binds FN1 dimer - Xenopus tropicalis [Reaction:R-DRE-202723] Integrin alpha5beta1 binds FN1 dimer - Danio rerio [Reaction:R-SSC-202723] Integrin alpha5beta1 binds FN1 dimer - Sus scrofa [Reaction:R-BTA-202723] Integrin alpha5beta1 binds FN1 dimer - Bos taurus [Reaction:R-CFA-202723] Integrin alpha5beta1 binds FN1 dimer - Canis familiaris [Reaction:R-RNO-202723] Integrin alpha5beta1 binds FN1 dimer - Rattus norvegicus [Reaction:R-MMU-202723] Integrin alpha5beta1 binds FN1 dimer - Mus musculus
output	[Complex:R-HSA-202708] Integrin alpha5beta1:FN1 dimer [plasma membrane]
precedingEvent	[Reaction:R-HSA-2545196] FN1 dimerizes - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-202743] Positive regulation by 'CEACAM heterodimer [plasma membrane]'
regulationReference	[RegulationReference:9642922] Positive regulation by 'CEACAM heterodimer [plasma membrane]' GPI-anchored CEA family glycoproteins CEA and CEACAM6 mediate their biological effects through enhanced integrin alpha5beta1-fibronectin interaction
releaseDate	2007-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:203274] Zwaginga, JJ, 2007-11-12 16:47:00 [InstanceEdit:266386] Yamada, K, Humphries, MJ, Hynes, R, 2008-05-07 08:53:37 [InstanceEdit:3095962] Reinhardt, Dieter P, 2013-02-08
revised	[InstanceEdit:4090280] Jupe, S, 2013-08-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-202723
summation	[Summation:203434] Alpha5beta1 integrin was the first integrin shown to bind fi...
updateTrackers	[UpdateTracker:9791802] Update Tracker - [Reaction:202723] Integrin alpha5beta1 binds FN1 dimer - v25:[add_removeInput] [UpdateTracker:9787280] Update Tracker - [Reaction:202723] Integrin alpha5beta1 binds FN1 dimer - v46:[addLiteratureReference, modifyText] [UpdateTracker:9787931] Update Tracker - [Reaction:202723] Integrin alpha5beta1 binds FN1 dimer - v44:[modifyText] [UpdateTracker:9786183] Update Tracker - [Reaction:202723] Integrin alpha5beta1 binds FN1 dimer - v50:[add_removeRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9791802] Update Tracker - [Reaction:202723] Integrin alpha5beta1 binds FN1 dimer - v25:[add_removeInput] [UpdateTracker:9787280] Update Tracker - [Reaction:202723] Integrin alpha5beta1 binds FN1 dimer - v46:[addLiteratureReference, modifyText] [UpdateTracker:9787931] Update Tracker - [Reaction:202723] Integrin alpha5beta1 binds FN1 dimer - v44:[modifyText] [UpdateTracker:9786183] Update Tracker - [Reaction:202723] Integrin alpha5beta1 binds FN1 dimer - v50:[add_removeRegulator]
(precedingEvent)	[BlackBoxEvent:R-HSA-2327746] FN1 aggregation
(hasEvent)	[Pathway:R-HSA-1566977] Fibronectin matrix formation [Pathway:R-HSA-202733] Cell surface interactions at the vascular wall

Cite Us!