Reactome | Integrin alpha5beta1 binds FN1 dimer

Schema > Reaction > Entries

Integrin alpha5beta1 binds FN1 dimer Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10245604
displayName	Integrin alpha5beta1 binds FN1 dimer
eventOf	[Pathway:R-CFA-1566977] Fibronectin matrix formation - Canis familiaris [Pathway:R-CFA-202733] Cell surface interactions at the vascular wall - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-CFA-2327746] FN1 aggregation - Canis familiaris
inferredFrom	[Reaction:R-HSA-202723] Integrin alpha5beta1 binds FN1 dimer - Homo sapiens
input	[Complex:R-CFA-266103] FN1 dimer [extracellular region] [Complex:R-CFA-202730] Integrin alpha5beta1 [plasma membrane] [SimpleEntity:R-ALL-266099] Mn2+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Integrin alpha5beta1 binds FN1 dimer
output	[Complex:R-CFA-202708] Integrin alpha5beta1:FN1 dimer [plasma membrane]
precedingEvent	[Reaction:R-CFA-2545196] FN1 dimerizes - Canis familiaris
regulatedBy	[PositiveRegulation:10245605] Positive regulation by 'CEACAM heterodimer [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-202723
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-1566977] Fibronectin matrix formation [Pathway:R-CFA-202733] Cell surface interactions at the vascular wall
(precedingEvent)	[BlackBoxEvent:R-CFA-2327746] FN1 aggregation
(inferredTo)	[Reaction:R-HSA-202723] Integrin alpha5beta1 binds FN1 dimer