Reactome | Integrin alpha4beta1 binds JAM2:JAM3

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Integrin alpha4beta1 binds JAM2:JAM3 Show undefined attributes

authored	[InstanceEdit:203275] Ouwehand, W.H., 2007-11-12 16:45:54
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:202725] de Bono, B, 2007-11-11 16:10:42
dbId	202706
displayName	Integrin alpha4beta1 binds JAM2:JAM3
eventOf	[Pathway:R-HSA-202733] Cell surface interactions at the vascular wall - Homo sapiens [Pathway:R-HSA-216083] Integrin cell surface interactions - Homo sapiens
input	[Complex:R-HSA-198201] ITGA4:ITGB1 [plasma membrane] [Complex:R-HSA-202761] JAM2:JAM3 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:202753] The role of junctional adhesion molecules in vascular inflammation [LiteratureReference:203312] JAM2 interacts with alpha4beta1. Facilitation by JAM3.
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	Integrin alpha4beta1 binds JAM2:JAM3
orthologousEvent	[Reaction:R-GGA-202706] Integrin alpha4beta1 binds JAM2:JAM3 - Gallus gallus [Reaction:R-XTR-202706] Integrin alpha4beta1 binds JAM2:JAM3 - Xenopus tropicalis [Reaction:R-DRE-202706] Integrin alpha4beta1 binds JAM2:JAM3 - Danio rerio [Reaction:R-SSC-202706] Integrin alpha4beta1 binds JAM2:JAM3 - Sus scrofa [Reaction:R-BTA-202706] Integrin alpha4beta1 binds JAM2:JAM3 - Bos taurus [Reaction:R-CFA-202706] Integrin alpha4beta1 binds JAM2:JAM3 - Canis familiaris [Reaction:R-RNO-202706] Integrin alpha4beta1 binds JAM2:JAM3 - Rattus norvegicus [Reaction:R-MMU-202706] Integrin alpha4beta1 binds JAM2:JAM3 - Mus musculus
output	[Complex:R-HSA-202759] integrin alpha4beta1:JAM2:JAM3 [plasma membrane]
precedingEvent	[Reaction:R-HSA-202721] JAM2 binds JAM3 - Homo sapiens
regulatedBy	[NegativeRegulation:9690528] Negative regulation by 'ITGA4:ITGB1:natalizumab [plasma membrane]'
regulationReference	[RegulationReference:9690530] Negative regulation by 'ITGA4:ITGB1:natalizumab [plasma membrane]' Anti-alpha4 integrin therapy for multiple sclerosis: mechanisms and rationale
releaseDate	2007-12-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:266386] Yamada, K, Humphries, MJ, Hynes, R, 2008-05-07 08:53:37
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-202706
summation	[Summation:203316] Several key IgSF cell adhesion molecules engage integrin and...
updateTrackers	[UpdateTracker:9786064] Update Tracker - [Reaction:202706] Integrin alpha4beta1 binds JAM2:JAM3 - v50:[add_removeInput, modifyText, removeRegulator] [UpdateTracker:9776885] Update Tracker - [Reaction:202706] Integrin alpha4beta1 binds JAM2:JAM3 - v74:[addRegulator, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9786064] Update Tracker - [Reaction:202706] Integrin alpha4beta1 binds JAM2:JAM3 - v50:[add_removeInput, modifyText, removeRegulator] [UpdateTracker:9776885] Update Tracker - [Reaction:202706] Integrin alpha4beta1 binds JAM2:JAM3 - v74:[addRegulator, modifyText]
(hasEvent)	[Pathway:R-HSA-202733] Cell surface interactions at the vascular wall [Pathway:R-HSA-216083] Integrin cell surface interactions

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