Reactome | Integrin alpha4beta1 binds JAM2:JAM3

Integrin alpha4beta1 binds JAM2:JAM3

Stable Identifier

R-HSA-202706

Type

Reaction [binding]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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Several key IgSF cell adhesion molecules engage integrin and in so doing impact on the multi-step paradigm of leukocyte emigration. The interaction between JAM2 (JAM-B) and Integrin alpha4beta1 (VLA-4) requires prior binding of JAM2 to JAM3 (JAM-C).

Literature References

PubMed ID	Title	Journal	Year
12070135	JAM2 interacts with alpha4beta1. Facilitation by JAM3. Tran, TM, Brock, TA, Cunningham, SA, Rodriguez, JM, Arrate, MP	J Biol Chem	2002
17525755	The role of junctional adhesion molecules in vascular inflammation Weber, C, Fraemohs, L, Dejana, E	Nat Rev Immunol	2007