Reactome | I-Smad competes with Co-Smad for R-Smad1/5/8

Schema > Reaction > Entries

I-Smad competes with Co-Smad for R-Smad1/5/8 Show undefined attributes

authored	[InstanceEdit:202631] Huminiecki, L, Moustakas, A, 2007-11-07 10:22:00
category	binding
compartment	[Compartment:947587] cytoplasmic side of plasma membrane
created	[InstanceEdit:202635] Jassal, B, 2007-11-07 13:11:04
dbId	202626
displayName	I-Smad competes with Co-Smad for R-Smad1/5/8
eventOf	[Pathway:R-HSA-201451] Signaling by BMP - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:23767] negative regulation of BMP signaling pathway
input	[DefinedSet:R-HSA-173495] I-SMAD [cytosol] [DefinedSet:R-HSA-201482] p-2S-SMAD1/5/8 [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:202621] Smad6 inhibits BMP/Smad1 signaling by specifically competing with the Smad4 tumor suppressor
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	I-Smad competes with Co-Smad for R-Smad1/5/8
orthologousEvent	[Reaction:R-DME-202626] I-Smad competes with Co-Smad for R-Smad1/5/8 - Drosophila melanogaster [Reaction:R-CEL-202626] I-Smad competes with Co-Smad for R-Smad1/5/8 - Caenorhabditis elegans [Reaction:R-GGA-202626] I-Smad competes with Co-Smad for R-Smad1/5/8 - Gallus gallus [Reaction:R-XTR-202626] I-Smad competes with Co-Smad for R-Smad1/5/8 - Xenopus tropicalis [Reaction:R-DRE-202626] I-Smad competes with Co-Smad for R-Smad1/5/8 - Danio rerio [Reaction:R-SSC-202626] I-Smad competes with Co-Smad for R-Smad1/5/8 - Sus scrofa [Reaction:R-BTA-202626] I-Smad competes with Co-Smad for R-Smad1/5/8 - Bos taurus [Reaction:R-CFA-202626] I-Smad competes with Co-Smad for R-Smad1/5/8 - Canis familiaris [Reaction:R-RNO-202626] I-Smad competes with Co-Smad for R-Smad1/5/8 - Rattus norvegicus [Reaction:R-MMU-202626] I-Smad competes with Co-Smad for R-Smad1/5/8 - Mus musculus
output	[Complex:R-HSA-202644] I-SMAD:p-2S-SMAD1/5/8 [cytosol]
precedingEvent	[Reaction:R-HSA-201453] Phospho-R-Smad1/5/8 dissociates from the receptor complex - Homo sapiens
releaseDate	2006-08-02
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:203122] Heldin, CH, 2007-11-12
revised	[InstanceEdit:9635710] Mi, Huaiyu, 2019-02-07
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-202626
summation	[Summation:202614] I-SMAD selectively antagonizes BMP-activated Smad1/5/9 by ac...

Referrals

(hasEvent)

[Pathway:R-HSA-201451] Signaling by BMP