Reactome | I-Smad competes with Co-Smad for R-Smad1/5/8

Schema > Reaction > Entries

I-Smad competes with Co-Smad for R-Smad1/5/8 Show undefined attributes

category	binding
compartment	[Compartment:947587] cytoplasmic side of plasma membrane
created	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
dbId	10748797
displayName	I-Smad competes with Co-Smad for R-Smad1/5/8
eventOf	[Pathway:R-GGA-201451] Signaling by BMP - Gallus gallus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:23767] negative regulation of BMP signaling pathway
inferredFrom	[Reaction:R-HSA-202626] I-Smad competes with Co-Smad for R-Smad1/5/8 - Homo sapiens
input	[DefinedSet:R-GGA-173495] I-SMAD [cytosol] [DefinedSet:R-GGA-201482] p-2S-SMAD1/5/8 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	I-Smad competes with Co-Smad for R-Smad1/5/8
output	[Complex:R-GGA-202644] I-SMAD:p-2S-SMAD1/5/8 [cytosol]
precedingEvent	[Reaction:R-GGA-201453] Phospho-R-Smad1/5/8 dissociates from the receptor complex - Gallus gallus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49591] Gallus gallus
stId	R-GGA-202626
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-GGA-201451] Signaling by BMP
(inferredTo)	[Reaction:R-HSA-202626] I-Smad competes with Co-Smad for R-Smad1/5/8

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