Reactome | Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity

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Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
catalystActivity	[CatalystActivity:2023458] protein tyrosine kinase activity of FGFR1 mutant dimers with enhanced kinase activity [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:2023461] Rothfels, K, 2011-12-07
dbId	2023460
disease	[Disease:1500689] cancer [Disease:2011833] glioblastoma
displayName	Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654448] gain_of_function of FGFR1 mutant dimers with enhanced kinase activity [plasma membrane]
eventOf	[Pathway:R-HSA-1839122] Signaling by activated point mutants of FGFR1 - Homo sapiens
input	16 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [CandidateSet:R-HSA-2023433] FGFR1 mutant dimers with enhanced kinase activity [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1614276] The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations [LiteratureReference:1614269] Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas [LiteratureReference:1295608] Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4 [LiteratureReference:1614246] Comprehensive genomic characterization defines human glioblastoma genes and core pathways [LiteratureReference:2054036] Effect of transmembrane and kinase domain mutations on fibroblast growth factor receptor 3 chimera signaling in PC12 cells. A model for the control of receptor tyrosine kinase activation [LiteratureReference:1637882] Drug-sensitive FGFR2 mutations in endometrial carcinoma [LiteratureReference:1637891] Frequent activating FGFR2 mutations in endometrial carcinomas parallel germline mutations associated with craniosynostosis and skeletal dysplasia syndromes [LiteratureReference:2033246] Genomic screening of fibroblast growth-factor receptor 2 reveals a wide spectrum of mutations in patients with syndromic craniosynostosis [LiteratureReference:2032916] A novel skeletal dysplasia with developmental delay and acanthosis nigricans is caused by a Lys650Met mutation in the fibroblast growth factor receptor 3 gene [LiteratureReference:2012013] Induction of chondrogenesis in neural crest cells by mutant fibroblast growth factor receptors
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity
output	[CandidateSet:R-HSA-2023432] Activated FGFR1 mutant dimers with enhanced kinase activity [plasma membrane] 16 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-2023456] Dimerization of FGFR1 point mutants with enhanced kinase activity - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2023460
summation	[Summation:2054057] The three kinase domain mutants of FGFR1 that have been iden...

Referrals

(hasEvent)

[Pathway:R-HSA-1839122] Signaling by activated point mutants of FGFR1