Reactome | Dimerization of FGFR1 point mutants with enhanced kinase activity

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Dimerization of FGFR1 point mutants with enhanced kinase activity Show undefined attributes

authored	[InstanceEdit:2105031] Rothfels, K, 2012-02-09
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:2023457] Rothfels, K, 2011-12-07
crossReference	[DatabaseIdentifier:12020790] Mondo:0018177
dbId	2023456
disease	[Disease:1500689] cancer [Disease:1247632] glioblastoma
displayName	Dimerization of FGFR1 point mutants with enhanced kinase activity
edited	[InstanceEdit:2252592] Rothfels, K, 2012-05-16
entityFunctionalStatus	[EntityFunctionalStatus:5654486] gain_of_function of FGFR1 mutants with enhanced kinase activity [plasma membrane]
eventOf	[Pathway:R-HSA-1839122] Signaling by activated point mutants of FGFR1 - Homo sapiens
followingEvent	[Reaction:R-HSA-2023460] Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity - Homo sapiens
input	2 × [CandidateSet:R-HSA-2012030] FGFR1 mutants with enhanced kinase activity [plasma membrane]
isChimeric	false
isInDisease	true
isInferred	false
literatureReference	[LiteratureReference:1614276] The precise sequence of FGF receptor autophosphorylation is kinetically driven and is disrupted by oncogenic mutations [LiteratureReference:1614269] Sequence survey of receptor tyrosine kinases reveals mutations in glioblastomas [LiteratureReference:1295608] Transformation and Stat activation by derivatives of FGFR1, FGFR3, and FGFR4 [LiteratureReference:2012013] Induction of chondrogenesis in neural crest cells by mutant fibroblast growth factor receptors [LiteratureReference:1614246] Comprehensive genomic characterization defines human glioblastoma genes and core pathways [LiteratureReference:2054036] Effect of transmembrane and kinase domain mutations on fibroblast growth factor receptor 3 chimera signaling in PC12 cells. A model for the control of receptor tyrosine kinase activation
maxDepth	1
modified	[InstanceEdit:9962056] Matthews, Lisa, 2025-07-30
name	Dimerization of FGFR1 point mutants with enhanced kinase activity
output	[CandidateSet:R-HSA-2023433] FGFR1 mutant dimers with enhanced kinase activity [plasma membrane]
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2248845] Ezzat, S, 2012-05-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-2023456
summation	[Summation:2054043] Large scale genomic characterization of glioblastoma tumors ...

Referrals

(hasEvent)	[Pathway:R-HSA-1839122] Signaling by activated point mutants of FGFR1
(precedingEvent)	[Reaction:R-HSA-2023460] Autocatalytic phosphorylation of FGFR1 mutants with enhanced kinase activity

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