Reactome | Vitamin B5 (pantothenate) metabolism

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Vitamin B5 (pantothenate) metabolism Show undefined attributes

authored	[InstanceEdit:199189] D'Eustachio, P, 2007-07-09 22:03:12
created	[InstanceEdit:199189] D'Eustachio, P, 2007-07-09 22:03:12
dbId	199220
displayName	Vitamin B5 (pantothenate) metabolism
doi	10.3180/R-HSA-199220.4
eventOf	[Pathway:R-HSA-196849] Metabolism of water-soluble vitamins and cofactors - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:25945] pantothenate metabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-HSA-8938314] ENPPs hydrolyse CoA-SH to PPANT, PAP - Homo sapiens [Reaction:R-HSA-8939039] PPANT translocates from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-8938300] Vanin hydrolyses pantetheine to PanK, 2AET - Homo sapiens [Reaction:R-HSA-199206] SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol - Homo sapiens [Pathway:R-HSA-196783] Coenzyme A biosynthesis - Homo sapiens [Reaction:R-HSA-199216] SLC25A16 transports cytosolic CoA-SH to mitochondrial matrix - Homo sapiens [Reaction:R-HSA-9837333] SLC25A42 exchanges cytosolic CoA-SH for mitochondrial matrix ADP - Homo sapiens [Reaction:R-HSA-199202] Phosphopantetheine conjugation of the ACP domain of FAS - Homo sapiens [Reaction:R-HSA-9837354] NUDT8 hydrolyzes CoA-SH to PPANT - Homo sapiens [Reaction:R-HSA-9837419] PANK4 hydrolyzes PPANT to pantetheine - Homo sapiens
isInDisease	false
isInferred	false
lastUpdatedDate	2023-09-13
literatureReference	[LiteratureReference:199204] Cloning, expression, and characterization of a human 4'-phosphopantetheinyl transferase with broad substrate specificity [LiteratureReference:196744] Coenzyme A metabolism
maxDepth	3
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Vitamin B5 (pantothenate) metabolism
orthologousEvent	[Pathway:R-PFA-199220] Vitamin B5 (pantothenate) metabolism - Plasmodium falciparum [Pathway:R-SCE-199220] Vitamin B5 (pantothenate) metabolism - Saccharomyces cerevisiae [Pathway:R-SPO-199220] Vitamin B5 (pantothenate) metabolism - Schizosaccharomyces pombe [Pathway:R-DDI-199220] Vitamin B5 (pantothenate) metabolism - Dictyostelium discoideum [Pathway:R-CEL-199220] Vitamin B5 (pantothenate) metabolism - Caenorhabditis elegans [Pathway:R-DME-199220] Vitamin B5 (pantothenate) metabolism - Drosophila melanogaster [Pathway:R-GGA-199220] Vitamin B5 (pantothenate) metabolism - Gallus gallus [Pathway:R-XTR-199220] Vitamin B5 (pantothenate) metabolism - Xenopus tropicalis [Pathway:R-DRE-199220] Vitamin B5 (pantothenate) metabolism - Danio rerio [Pathway:R-SSC-199220] Vitamin B5 (pantothenate) metabolism - Sus scrofa [Pathway:R-BTA-199220] Vitamin B5 (pantothenate) metabolism - Bos taurus [Pathway:R-CFA-199220] Vitamin B5 (pantothenate) metabolism - Canis familiaris [Pathway:R-RNO-199220] Vitamin B5 (pantothenate) metabolism - Rattus norvegicus [Pathway:R-MMU-199220] Vitamin B5 (pantothenate) metabolism - Mus musculus
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2007-08-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9840788] Hill, David P, 2023-07-26
revised	[InstanceEdit:5359004] Jassal, Bijay, 2014-04-07
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-199220
summation	[Summation:199191] Vitamin B5 ((R)-pantothenate, PanK), is an essential precurs...
updateTrackers	[UpdateTracker:9787520] Update Tracker - [Pathway:199220] Vitamin B5 (pantothenate) metabolism - v44:[updateContainedRLE, updateIndirectRLE] [UpdateTracker:9842279] Update Tracker - [Pathway:199220] Vitamin B5 (pantothenate) metabolism - v86:[addHasEvent, modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE] [UpdateTracker:9791693] Update Tracker - [Pathway:199220] Vitamin B5 (pantothenate) metabolism - v27:[updateIndirectRLE] [UpdateTracker:9782190] Update Tracker - [Pathway:199220] Vitamin B5 (pantothenate) metabolism - v59:[addHasEvent] [UpdateTracker:9789413] Update Tracker - [Pathway:199220] Vitamin B5 (pantothenate) metabolism - v38:[addLiteratureReference, modifyText] [UpdateTracker:9786555] Update Tracker - [Pathway:199220] Vitamin B5 (pantothenate) metabolism - v49:[updateContainedRLE]

Referrals

(updatedInstance)

[UpdateTracker:9787520] Update Tracker - [Pathway:199220] Vitamin B5 (pantothenate) metabolism - v44:[updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9842279] Update Tracker - [Pathway:199220] Vitamin B5 (pantothenate) metabolism - v86:[addHasEvent, modifyText, updateContainedPathway, updateContainedRLE, updateIndirectRLE]
[UpdateTracker:9791693] Update Tracker - [Pathway:199220] Vitamin B5 (pantothenate) metabolism - v27:[updateIndirectRLE]
[UpdateTracker:9782190] Update Tracker - [Pathway:199220] Vitamin B5 (pantothenate) metabolism - v59:[addHasEvent]
[UpdateTracker:9789413] Update Tracker - [Pathway:199220] Vitamin B5 (pantothenate) metabolism - v38:[addLiteratureReference, modifyText]
[UpdateTracker:9786555] Update Tracker - [Pathway:199220] Vitamin B5 (pantothenate) metabolism - v49:[updateContainedRLE]

(hasEvent)

[Pathway:R-HSA-196849] Metabolism of water-soluble vitamins and cofactors

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