Reactome | p-T308,S473-AKT1 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

p-T308,S473-AKT1 [cytosol] Show undefined attributes

catalystActivities	[CatalystActivity:450501] protein serine/threonine kinase activity of p-T308,S473-AKT1 [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-202121] p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-6811504] AKT1 dephosphorylation by PP2A-B56-beta,gamma - Homo sapiens [Reaction:R-HSA-202137] AKT1 binds eNOS complex via HSP90 - Homo sapiens
created	[InstanceEdit:198362] Jassal, B, 2007-06-11 10:01:50
dbId	198356
displayName	p-T308,S473-AKT1 [cytosol]
endCoordinate	480
hasModifiedResidue	[ModifiedResidue:198329] O-phospho-L-threonine at 308 [ModifiedResidue:198374] O-phospho-L-serine at 473
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-198356] phospho-p-T308,S473-AKT1 [cytosol] - Mus musculus [EntityWithAccessionedSequence:R-RNO-198356] phospho-p-T308,S473-AKT1 [cytosol] - Rattus norvegicus [GenomeEncodedEntity:R-BTA-198356] Ghost homologue of p-T308,S473-AKT1 [cytosol] - Bos taurus [EntityWithAccessionedSequence:R-DRE-198356] phospho-p-T308,S473-AKT1 [cytosol] - Danio rerio [EntityWithAccessionedSequence:R-GGA-198356] phospho-p-T308,S473-AKT1 [cytosol] - Gallus gallus [EntityWithAccessionedSequence:R-DME-198356] phospho-p-T308,S473-AKT1 [cytosol] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-198356] phospho-p-T308,S473-AKT1 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-198356-2] phospho-p-T308,S473-AKT1 [cytosol] - Caenorhabditis elegans [DefinedSet:R-CEL-198356-3] Homologues of p-T308,S473-AKT1 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-DDI-198356] phospho-p-T308,S473-AKT1 [cytosol] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-DDI-198356-2] phospho-p-T308,S473-AKT1 [cytosol] - Dictyostelium discoideum [DefinedSet:R-DDI-198356-3] Homologues of p-T308,S473-AKT1 [cytosol] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-SPO-198356] phospho-p-T308,S473-AKT1 [cytosol] - Schizosaccharomyces pombe [EntityWithAccessionedSequence:R-SPO-198356-2] phospho-p-T308,S473-AKT1 [cytosol] - Schizosaccharomyces pombe [DefinedSet:R-SPO-198356-3] Homologues of p-T308,S473-AKT1 [cytosol] - Schizosaccharomyces pombe [EntityWithAccessionedSequence:R-SCE-198356] phospho-p-T308,S473-AKT1 [cytosol] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-198356-2] phospho-p-T308,S473-AKT1 [cytosol] - Saccharomyces cerevisiae [DefinedSet:R-SCE-198356-3] Homologues of p-T308,S473-AKT1 [cytosol] - Saccharomyces cerevisiae
maxDepth	1
memberOf	[DefinedSet:R-HSA-9975697] p-T,p-S-AKT [cytosol] - Homo sapiens
modified	[InstanceEdit:3632907] Wu, G, 2013-05-28
name	p-T308,S473-AKT1 p-S473,T308-AKT1 p-T308, S473-AKT1 RAC-alpha serine/threonine kinase RAC-PK-alpha Protein kinase B PKB C-AKT
producedByEvent	[BlackBoxEvent:R-HSA-9906597] Activation of AKT1 by shear stress in osteocytes - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:P31749] UniProt:P31749 AKT1
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-198356
startCoordinate	1
updateTrackers	[UpdateTracker:9870446] Update Tracker - [EntityWithAccessionedSequence:198356] p-T308,S473-AKT1 [cytosol] - v38:[modifyName] [UpdateTracker:9885231] Update Tracker - [EntityWithAccessionedSequence:198356] p-T308,S473-AKT1 [cytosol] - v45:[addName] [UpdateTracker:9868480] Update Tracker - [EntityWithAccessionedSequence:198356] p-T308,S473-AKT1 [cytosol] - v31:[removeName] [UpdateTracker:9877098] Update Tracker - [EntityWithAccessionedSequence:198356] p-T308,S473-AKT1 [cytosol] - v44:[modifyEndCoordinate]

Referrals

(updatedInstance)	[UpdateTracker:9870446] Update Tracker - [EntityWithAccessionedSequence:198356] p-T308,S473-AKT1 [cytosol] - v38:[modifyName] [UpdateTracker:9885231] Update Tracker - [EntityWithAccessionedSequence:198356] p-T308,S473-AKT1 [cytosol] - v45:[addName] [UpdateTracker:9868480] Update Tracker - [EntityWithAccessionedSequence:198356] p-T308,S473-AKT1 [cytosol] - v31:[removeName] [UpdateTracker:9877098] Update Tracker - [EntityWithAccessionedSequence:198356] p-T308,S473-AKT1 [cytosol] - v44:[modifyEndCoordinate]
(output)	[BlackBoxEvent:R-HSA-9906597] Activation of AKT1 by shear stress in osteocytes
(input)	[Reaction:R-HSA-202137] AKT1 binds eNOS complex via HSP90 [Reaction:R-HSA-6811504] AKT1 dephosphorylation by PP2A-B56-beta,gamma
(hasComponent)	[Complex:R-HSA-202121] p-S1177-eNOS:CaM:HSP90:p-AKT1 [plasma membrane] [Complex:R-HSA-1497889] p-S1177-eNOS:CaM:HSP90:p-AKT1:BH2 [plasma membrane]
(hasMember)	[DefinedSet:R-HSA-9975697] p-T,p-S-AKT [cytosol] [CandidateSet:R-HSA-202074] p-T,p-S-AKT [cytosol]
(physicalEntity)	[CatalystActivity:450501] protein serine/threonine kinase activity of p-T308,S473-AKT1 [cytosol]

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