Reactome | NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer

Schema > Reaction > Entries

NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer Show undefined attributes

authored	[InstanceEdit:1972351] Orlic-Milacic, M, 2011-11-04 [InstanceEdit:9638819] Stern, David F, 2019-02-21
catalystActivity	[CatalystActivity:1977300] ubiquitin-protein transferase activity of ERBB4jmAcyt1s80:NEDD4 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1977298] Orlic-Milacic, M, 2011-11-07
dbId	1977296
displayName	NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer
edited	[InstanceEdit:1972361] Matthews, L, 2011-11-07 [InstanceEdit:9638824] Orlic-Milacic, Marija, 2019-03-05
eventOf	[Pathway:R-HSA-1253288] Downregulation of ERBB4 signaling - Homo sapiens
input	[Complex:R-HSA-1973959] ERBB4jmAcyt1s80:NEDD4 [cytosol] [DefinedSet:R-HSA-113595] Ub [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1973946] Nedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cells
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer
orthologousEvent	[Reaction:R-CFA-1977296] NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer - Canis familiaris [Reaction:R-CEL-1977296] NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer - Caenorhabditis elegans [Reaction:R-DME-1977296] NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer - Drosophila melanogaster [Reaction:R-GGA-1977296] NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer - Gallus gallus [Reaction:R-SSC-1977296] NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer - Sus scrofa [Reaction:R-BTA-1977296] NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer - Bos taurus [Reaction:R-RNO-1977296] NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer - Rattus norvegicus [Reaction:R-MMU-1977296] NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer - Mus musculus
output	[Complex:R-HSA-1977297] Ub-ERBB4jmAcyt1s80:NEDD4 [cytosol]
precedingEvent	[Reaction:R-HSA-1973956] NEDD4 binds ERBB4jmAcyt1s80 dimer - Homo sapiens
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1979910] Harris, RC, 2011-11-11 [InstanceEdit:1979909] Zeng, F, 2011-11-11
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1977296
summation	[Summation:1977299] E3 ubiquitin ligase NEDD4 mediates ubiquitination of ERBB4 J...
updateTrackers	[UpdateTracker:9779355] Update Tracker - [Reaction:1977296] NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer - v65:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9779355] Update Tracker - [Reaction:1977296] NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer - v65:[modifyText]
(hasEvent)	[Pathway:R-HSA-1253288] Downregulation of ERBB4 signaling