NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer

Stable Identifier
R-HSA-1977296
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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E3 ubiquitin ligase NEDD4 mediates ubiquitination of ERBB4 JM-A CYT-1 intracellular domain s80 (ERBB4jmAcyt1s80) produced by ERBB4 cleavage. This induces degradation of ERBB4jmAcyt1s80, and decreases the amount of ERBB4jmAcyt1s80 that reaches the nucleus (Zeng et al. 2009).

Literature References
PubMed ID Title Journal Year
19193720 Nedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cells

Zeng, F, Xu, J, Harris, RC

FASEB J 2009
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
ubiquitin-protein transferase activity of ERBB4jmAcyt1s80:NEDD4 [cytosol]
Physical Entity
Activity
Orthologous Events
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Reviewed
Created