NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer

Stable Identifier
R-HSA-1977296
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
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NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer
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E3 ubiquitin ligase NEDD4 mediates ubiquitination of ERBB4 JM-A CYT-1 intracellular domain s80 (ERBB4jmAcyt1s80) produced by ERBB4 cleavage. This induces degradation of ERBB4jmAcyt1s80, and decreases the amount of ERBB4jmAcyt1s80 that reaches the nucleus (Zeng et al. 2009).
Literature References
PubMed ID Title Journal Year
19193720 Nedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cells

Harris, RC, Zeng, F, Xu, J

FASEB J 2009
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Catalyst Activity

ubiquitin-protein transferase activity of ERBB4jmAcyt1s80:NEDD4 [cytosol]

Physical Entity
ERBB4jmAcyt1s80:NEDD4 [cytosol] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Orthologous Events
NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Bos taurus)
NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Caenorhabditis elegans)
NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Canis familiaris)
NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Danio rerio)
NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Drosophila melanogaster)
NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Gallus gallus)
NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Mus musculus)
NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Rattus norvegicus)
NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer (Sus scrofa)
Authored
Orlic-Milacic, M  (2011-11-04)
Stern, DF  (2019-02-21)
Reviewed
Zeng, F  (2011-11-11)
Harris, RC  (2011-11-11)
Created
Orlic-Milacic, M  (2011-11-08)
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