NEDD4 ubiquitinates ERBB4jmAcyt1s80 dimer

Stable Identifier
R-HSA-1977296
Type
Reaction
Species
Homo sapiens
Compartment
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E3 ubiquitin ligase NEDD4 mediates ubiquitination of ERBB4 JM-A CYT-1 intracellular domain s80 (ERBB4jmAcyt1s80) produced by ERBB4 cleavage. This induces degradation of ERBB4jmAcyt1s80, and decreases the amount of ERBB4jmAcyt1s80 that reaches the nucleus (Zeng et al. 2009).

Literature References
PubMed ID Title Journal Year
19193720 Nedd4 mediates ErbB4 JM-a/CYT-1 ICD ubiquitination and degradation in MDCK II cells

Harris, RC, Zeng, F, Xu, J

FASEB J 2009
Participants
Participates
Catalyst Activity

ubiquitin-protein transferase activity of ERBB4jmAcyt1s80:NEDD4 [cytosol]

Orthologous Events
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