Reactome | 2xENPP1 hydrolyzes FAD to FMN

Schema > Reaction > Entries

2xENPP1 hydrolyzes FAD to FMN Show undefined attributes

catalystActivity	[CatalystActivity:196942] dinucleotide phosphatase activity of 2xENPP1 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:196936] Jassal, B, 2007-04-27 13:02:52
crossReference	[DatabaseIdentifier:12668303] RHEA:13890
dbId	196955
displayName	2xENPP1 hydrolyzes FAD to FMN
eventOf	[Pathway:R-HSA-196843] Vitamin B2 (riboflavin) metabolism - Homo sapiens
followingEvent	[Reaction:R-HSA-196950] 2xTRAP hydrolyzes FMN to RIB - Homo sapiens [Reaction:R-HSA-196929] FLAD1 phosphorylates FMN - Homo sapiens
input	[SimpleEntity:R-ALL-29386] FAD [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:196979] Biochemical characterization of human PC-1, an enzyme possessing alkaline phosphodiesterase I and nucleotide pyrophosphatase activities
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	2xENPP1 hydrolyzes FAD to FMN FAD + H2O => AMP + FMN + 2 H(+) FAD can be hydrolyzed back to FMN
orthologousEvent	[Reaction:R-SCE-196955] 2xENPP1 hydrolyzes FAD to FMN - Saccharomyces cerevisiae [Reaction:R-SPO-196955] 2xENPP1 hydrolyzes FAD to FMN - Schizosaccharomyces pombe [Reaction:R-DDI-196955] 2xENPP1 hydrolyzes FAD to FMN - Dictyostelium discoideum [Reaction:R-CEL-196955] 2xENPP1 hydrolyzes FAD to FMN - Caenorhabditis elegans [Reaction:R-GGA-196955] 2xENPP1 hydrolyzes FAD to FMN - Gallus gallus [Reaction:R-XTR-196955] 2xENPP1 hydrolyzes FAD to FMN - Xenopus tropicalis [Reaction:R-DRE-196955] 2xENPP1 hydrolyzes FAD to FMN - Danio rerio [Reaction:R-SSC-196955] 2xENPP1 hydrolyzes FAD to FMN - Sus scrofa [Reaction:R-BTA-196955] 2xENPP1 hydrolyzes FAD to FMN - Bos taurus [Reaction:R-CFA-196955] 2xENPP1 hydrolyzes FAD to FMN - Canis familiaris [Reaction:R-RNO-196955] 2xENPP1 hydrolyzes FAD to FMN - Rattus norvegicus [Reaction:R-MMU-196955] 2xENPP1 hydrolyzes FAD to FMN - Mus musculus
output	[SimpleEntity:R-ALL-76577] AMP [cytosol] [SimpleEntity:R-ALL-73524] FMN [cytosol] 2 × [SimpleEntity:R-ALL-70106] H+ [cytosol]
precedingEvent	[Reaction:R-HSA-196929] FLAD1 phosphorylates FMN - Homo sapiens
previousReviewStatus	[ReviewStatus:9821384] two stars
releaseDate	2005-09-26
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9840788] Hill, David P, 2023-07-26
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-196955
summation	[Summation:196932] Phosphatase action on flavin adenine dinucleotide (FAD) can ...
updateTrackers	[UpdateTracker:9842270] Update Tracker - [Reaction:196955] 2xENPP1 hydrolyzes FAD to FMN - v86:[addOutput] [UpdateTracker:9790568] Update Tracker - [Reaction:196955] 2xENPP1 hydrolyzes FAD to FMN - v33:[add_removeOutput] [UpdateTracker:9787785] Update Tracker - [Reaction:196955] 2xENPP1 hydrolyzes FAD to FMN - v44:[modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9842270] Update Tracker - [Reaction:196955] 2xENPP1 hydrolyzes FAD to FMN - v86:[addOutput] [UpdateTracker:9790568] Update Tracker - [Reaction:196955] 2xENPP1 hydrolyzes FAD to FMN - v33:[add_removeOutput] [UpdateTracker:9787785] Update Tracker - [Reaction:196955] 2xENPP1 hydrolyzes FAD to FMN - v44:[modifyText]
(hasEvent)	[Pathway:R-HSA-196843] Vitamin B2 (riboflavin) metabolism
(precedingEvent)	[Reaction:R-HSA-196929] FLAD1 phosphorylates FMN [Reaction:R-HSA-196950] 2xTRAP hydrolyzes FMN to RIB