Reactome | Reduction of isocaproaldehyde to 4-methylpentan-1-ol

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Reduction of isocaproaldehyde to 4-methylpentan-1-ol Show undefined attributes

catalystActivity	[CatalystActivity:196106] aldose reductase (NADPH) activity of AKR1B1 [cytosol]
catalystActivityReference	[CatalystActivityReference:9644770] alditol:NADP+ 1-oxidoreductase activity of AKR1B1 [cytosol] Aldose reductase is a major reductase for isocaproaldehyde, a product of side-chain cleavage of cholesterol, in human and animal adrenal glands
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:196115] D'Eustachio, P, 2007-04-17 18:04:28
crossReference	[DatabaseIdentifier:12668309] RHEA:58438
dbId	196060
displayName	Reduction of isocaproaldehyde to 4-methylpentan-1-ol
eventOf	[Pathway:R-HSA-196108] Pregnenolone biosynthesis - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-196095] ISCAL [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:196074] Aldose reductase is a major reductase for isocaproaldehyde, a product of side-chain cleavage of cholesterol, in human and animal adrenal glands
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Reduction of isocaproaldehyde to 4-methylpentan-1-ol isocaproaldehyde + NADPH + H+ => 4-methylpentan-1-ol + NADP+
orthologousEvent	[Reaction:R-SCE-196060] Reduction of isocaproaldehyde to 4-methylpentan-1-ol - Saccharomyces cerevisiae [Reaction:R-SPO-196060] Reduction of isocaproaldehyde to 4-methylpentan-1-ol - Schizosaccharomyces pombe [Reaction:R-DDI-196060] Reduction of isocaproaldehyde to 4-methylpentan-1-ol - Dictyostelium discoideum [Reaction:R-CEL-196060] Reduction of isocaproaldehyde to 4-methylpentan-1-ol - Caenorhabditis elegans [Reaction:R-DME-196060] Reduction of isocaproaldehyde to 4-methylpentan-1-ol - Drosophila melanogaster [Reaction:R-GGA-196060] Reduction of isocaproaldehyde to 4-methylpentan-1-ol - Gallus gallus [Reaction:R-XTR-196060] Reduction of isocaproaldehyde to 4-methylpentan-1-ol - Xenopus tropicalis [Reaction:R-DRE-196060] Reduction of isocaproaldehyde to 4-methylpentan-1-ol - Danio rerio [Reaction:R-SSC-196060] Reduction of isocaproaldehyde to 4-methylpentan-1-ol - Sus scrofa [Reaction:R-BTA-196060] Reduction of isocaproaldehyde to 4-methylpentan-1-ol - Bos taurus [Reaction:R-CFA-196060] Reduction of isocaproaldehyde to 4-methylpentan-1-ol - Canis familiaris [Reaction:R-RNO-196060] Reduction of isocaproaldehyde to 4-methylpentan-1-ol - Rattus norvegicus [Reaction:R-MMU-196060] Reduction of isocaproaldehyde to 4-methylpentan-1-ol - Mus musculus
output	[SimpleEntity:R-ALL-196066] MePeOH [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-HSA-196125] Translocation of isocaproaldehyde from the mitochondrial matrix to the cytosol - Homo sapiens
releaseDate	2007-05-15
reviewStatus	[ReviewStatus:9821382] five stars
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-196060
summation	[Summation:196087] Isocaproaldehyde is reduced by NADPH + H+ to yield 4-methyl...

Referrals

(hasEvent)

[Pathway:R-HSA-196108] Pregnenolone biosynthesis