Reactome | VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization

Schema > Reaction > Entries

VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization Show undefined attributes

authored	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:194309] Gopinathrao, G, 2007-03-12 19:24:15
dbId	194311
displayName	VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization
edited	[InstanceEdit:4420157] Garapati, P V, 2013-08-30
eventOf	[Pathway:R-HSA-195399] VEGF binds to VEGFR leading to receptor dimerization - Homo sapiens
figure	[Figure:195519] /figures/vegfr1.jpg
input	[DefinedSet:R-HSA-195389] VEGFA,VEGFB,PGF dimers [extracellular region] 2 × [EntityWithAccessionedSequence:R-HSA-3004464] VEGFR1 [plasma membrane]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:195484] A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells [LiteratureReference:195498] Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules [LiteratureReference:195485] Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site [LiteratureReference:195521] Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders [LiteratureReference:195503] Vascular endothelial growth factor is a secreted angiogenic mitogen [LiteratureReference:195458] Vascular endothelial growth factor B, a novel growth factor for endothelial cells
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization
orthologousEvent	[Reaction:R-GGA-194311] VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization - Gallus gallus [Reaction:R-DRE-194311] VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization - Danio rerio [Reaction:R-SSC-194311] VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization - Sus scrofa [Reaction:R-BTA-194311] VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization - Bos taurus [Reaction:R-CFA-194311] VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization - Canis familiaris [Reaction:R-RNO-194311] VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization - Rattus norvegicus [Reaction:R-MMU-194311] VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization - Mus musculus
output	[Complex:R-HSA-195396] VEGFR1 dimer:VEGFA, VEGFB, PGF dimers [plasma membrane]
precedingEvent	[Reaction:R-HSA-195378] Homodimerization of VEGF proteins - Homo sapiens
releaseDate	2008-03-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:215257] Claesson-Welsh, L, 2008-02-28 00:15:17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-194311
summation	[Summation:195576] VEGFR-1 binds VEGF-A, VEGF-B, and PLGF homodimers. This inte...
updateTrackers	[UpdateTracker:9787950] Update Tracker - [Reaction:194311] VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization - v44:[add_removeInput] [UpdateTracker:9786417] Update Tracker - [Reaction:194311] VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization - v49:[removeLiteratureReference]

Referrals

(updatedInstance)	[UpdateTracker:9787950] Update Tracker - [Reaction:194311] VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization - v44:[add_removeInput] [UpdateTracker:9786417] Update Tracker - [Reaction:194311] VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization - v49:[removeLiteratureReference]
(hasEvent)	[Pathway:R-HSA-195399] VEGF binds to VEGFR leading to receptor dimerization

Cite Us!