Reactome | VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization

VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization

Stable Identifier

R-HSA-194311

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

VEGFR-1 binds VEGF-A, VEGF-B, and PLGF homodimers. This interaction is required for normal angiogenesis and hematopoiesis, although many of the detailed molecular steps from binding to these physiological consequences remain unclear (Hickins and Ellis, 2005). VEGFR-1 is made up of 1338 aa and has three regions: an extracellular region consisting of 7 immunoglobin-like domains, a transmembrane (TM) domain and a cytosolic tyrosine kinase (TK) domain. An alternatively spliced form, soluble VEGFR-1 (sVEGFR1), also binds VEGF proteins and may serve in the body to down-regulate VEGF activation of membrane-bound receptors. Overexpression of sVEGFR1 (VEGF121) is associated with preeclampsia, a major disorder of pregnancy (Shibuya and Claesson-Welsh 2006; Levine et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
9207067	Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site de Vos, AM, Christinger, HW, Muller, YA, Cunningham, BC, Wells, JA, Li, B	Proc Natl Acad Sci U S A	1997
11387210	A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells Chida, K, Shibuya, M, Takahashi, T, Yamaguchi, S	EMBO J	2001
2479986	Vascular endothelial growth factor is a secreted angiogenic mitogen Kuang, WJ, Cachianes, G, Leung, DW, Ferrara, N, Goeddel, DV	Science	1989
9722576	Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules Engstrom, U, Claesson-Welsh, L, Ito, N, Wernstedt, C	J Biol Chem	1998
12871269	Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders Luttun, A, Tjwa, M, Carmeliet, P, Autiero, M	J Thromb Haemost	2003
8637916	Vascular endothelial growth factor B, a novel growth factor for endothelial cells Alitalo, K, von Euler, G, Kaipainen, A, Pettersson, RF, Eriksson, U, Orpana, A, Olofsson, B, Pajusola, K, Saksela, O, Joukov, V	Proc Natl Acad Sci U S A	1996