Reactome | VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization

VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization

Stable Identifier

R-HSA-194311

Type

Reaction [binding]

Species

Homo sapiens

Compartment

extracellular region, plasma membrane

ReviewStatus

5/5

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VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization

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VEGFR-1 binds VEGF-A, VEGF-B, and PLGF homodimers. This interaction is required for normal angiogenesis and hematopoiesis, although many of the detailed molecular steps from binding to these physiological consequences remain unclear (Hickins and Ellis, 2005). VEGFR-1 is made up of 1338 aa and has three regions: an extracellular region consisting of 7 immunoglobin-like domains, a transmembrane (TM) domain and a cytosolic tyrosine kinase (TK) domain. An alternatively spliced form, soluble VEGFR-1 (sVEGFR1), also binds VEGF proteins and may serve in the body to down-regulate VEGF activation of membrane-bound receptors. Overexpression of sVEGFR1 (VEGF121) is associated with preeclampsia, a major disorder of pregnancy (Shibuya and Claesson-Welsh 2006; Levine et al. 2004).

Literature References

PubMed ID	Title	Journal	Year
9207067	Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site Muller, YA, Li, B, Christinger, HW, Wells, JA, Cunningham, BC, de Vos, AM	Proc Natl Acad Sci U S A	1997
11387210	A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells Takahashi, T, Yamaguchi, S, Chida, K, Shibuya, M	EMBO J	2001
2479986	Vascular endothelial growth factor is a secreted angiogenic mitogen Leung, DW, Cachianes, G, Kuang, WJ, Goeddel, DV, Ferrara, N	Science	1989
9722576	Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules Ito, N, Wernstedt, C, Engstrom, U, Claesson-Welsh, L	J Biol Chem	1998
12871269	Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders Autiero, M, Luttun, A, Tjwa, M, Carmeliet, P	J Thromb Haemost	2003
8637916	Vascular endothelial growth factor B, a novel growth factor for endothelial cells Olofsson, B, Pajusola, K, Kaipainen, A, von Euler, G, Joukov, V, Saksela, O, Orpana, A, Pettersson, RF, Alitalo, K, Eriksson, U	Proc Natl Acad Sci U S A	1996