VEGFA,B,PLGF bind to VEGFR1 leading to receptor dimerization

Stable Identifier
R-HSA-194311
Type
Reaction [binding]
Species
Homo sapiens
Compartment
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VEGFR-1 binds VEGF-A, VEGF-B, and PLGF homodimers. This interaction is required for normal angiogenesis and hematopoiesis, although many of the detailed molecular steps from binding to these physiological consequences remain unclear (Hickins and Ellis, 2005). VEGFR-1 is made up of 1338 aa and has three regions: an extracellular region consisting of 7 immunoglobin-like domains, a transmembrane (TM) domain and a cytosolic tyrosine kinase (TK) domain. An alternatively spliced form, soluble VEGFR-1 (sVEGFR1), also binds VEGF proteins and may serve in the body to down-regulate VEGF activation of membrane-bound receptors. Overexpression of sVEGFR1 (VEGF121) is associated with preeclampsia, a major disorder of pregnancy (Shibuya and Claesson-Welsh 2006; Levine et al. 2004).

Literature References
PubMed ID Title Journal Year
11387210 A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells

Takahashi, T, Yamaguchi, S, Chida, K, Shibuya, M

EMBO J 2001
9207067 Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site

Muller, YA, Li, B, Christinger, HW, Wells, JA, Cunningham, BC, de Vos, AM

Proc Natl Acad Sci U S A 1997
2479986 Vascular endothelial growth factor is a secreted angiogenic mitogen

Leung, DW, Cachianes, G, Kuang, WJ, Goeddel, DV, Ferrara, N

Science 1989
9722576 Identification of vascular endothelial growth factor receptor-1 tyrosine phosphorylation sites and binding of SH2 domain-containing molecules

Ito, N, Wernstedt, C, Engstrom, U, Claesson-Welsh, L

J Biol Chem 1998
12871269 Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischemic tissue revascularization and inhibition of angiogenic and inflammatory disorders

Autiero, M, Luttun, A, Tjwa, M, Carmeliet, P

J Thromb Haemost 2003
8637916 Vascular endothelial growth factor B, a novel growth factor for endothelial cells

Olofsson, B, Pajusola, K, Kaipainen, A, von Euler, G, Joukov, V, Saksela, O, Orpana, A, Pettersson, RF, Alitalo, K, Eriksson, U

Proc Natl Acad Sci U S A 1996
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