Reactome | snRNP complex assembly

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snRNP complex assembly Show undefined attributes

authored	[InstanceEdit:192216] Gillespie, ME, 2007-01-29 20:29:54
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:191793] Gillespie, ME, 2007-01-25 05:18:34
dbId	191786
displayName	snRNP complex assembly
eventOf	[Pathway:R-HSA-191859] snRNP Assembly - Homo sapiens [Pathway:R-HSA-9754678] SARS-CoV-2 modulates host translation machinery - Homo sapiens
figure	[Figure:191797] /figures/snRNPAssembly_assembly.jpg
followingEvent	[Reaction:R-HSA-191784] snRNA Cap hypermethylation - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:81927] spliceosomal snRNP assembly
input	[Complex:R-HSA-191853] m7G capped Spliceosomal snRNA [cytosol] [Complex:R-HSA-191791] SMN:SM protein complex [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:191879] SMN-mediated assembly of RNPs: a complex story [LiteratureReference:191856] Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy [LiteratureReference:191851] A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	snRNP complex assembly
output	[Complex:R-HSA-191813] Spliceosomal m7G capped snRNAs with SMN:SM protein complex bound [cytosol]
precedingEvent	[Reaction:R-HSA-191790] Loading and methylation of Sm proteins onto SMN Complexes - Homo sapiens [Reaction:R-HSA-191825] Nuclear export of snRNA transcripts - Homo sapiens
regulatedBy	[NegativeRegulation:9766203] Negative regulation by 'U1 snRNA:nsp16 [nucleoplasm]' [NegativeRegulation:9766204] Negative regulation by 'U2 snRNA:nsp16 [nucleoplasm]'
regulationReference	[RegulationReference:9766210] Negative regulation by 'U1 snRNA:nsp16 [nucleoplasm]' SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses
releaseDate	2007-05-15
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:197146] Luhrmann, R, 2007-04-30 18:31:22 [InstanceEdit:9766195] Messina, Francesco, 2022-02-18
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-191786
summation	[Summation:191816] To facilitate snRNP assembly, the SMN complex must bring tog...
updateTrackers	[UpdateTracker:9775161] Update Tracker - [Reaction:191786] snRNP complex assembly - v80:[addRegulator, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9775161] Update Tracker - [Reaction:191786] snRNP complex assembly - v80:[addRegulator, modifyText]
(hasEvent)	[Pathway:R-HSA-191859] snRNP Assembly [Pathway:R-HSA-9754678] SARS-CoV-2 modulates host translation machinery
(precedingEvent)	[Reaction:R-HSA-191784] snRNA Cap hypermethylation