snRNP complex assembly

Stable Identifier
Reaction [binding]
Homo sapiens
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To facilitate snRNP assembly, the SMN complex must bring together the Sm proteins and a Sm-site-containing snRNA. The SMN:Sm protein complex binds to the m7G capped snRNAs in the cytoplasm.

SARS-CoV-2 nonstructural protein 16 (nsp16) binds to the 5′ splice site recognition sequence of U1 snRNA and the branchpoint recognition site of U2 snRNA, both parts of the spliceosome, disrupting global mRNA splicing (Banerjee et al, 2020).

Literature References
PubMed ID Title Journal Year
9845364 A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing

Kataoka, N, Dreyfuss, G, Charroux, B, Pellizzoni, L

Cell 1998
12441251 SMN-mediated assembly of RNPs: a complex story

Eggert, C, Fischer, U, Meister, G

Trends Cell Biol 2002
10556282 Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy

Luhrmann, R, Buhler, D, Raker, V, Fischer, U

Hum Mol Genet 1999
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