snRNP complex assembly

Stable Identifier
R-HSA-191786
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

To facilitate snRNP assembly, the SMN complex must bring together the Sm proteins and a Sm-site-containing snRNA. The SMN:Sm protein complex binds to the m7G capped snRNAs in the cytoplasm.

SARS-CoV-2 nonstructural protein 16 (nsp16) binds to the 5′ splice site recognition sequence of U1 snRNA and the branchpoint recognition site of U2 snRNA, both parts of the spliceosome, disrupting global mRNA splicing (Banerjee et al, 2020).

Literature References
PubMed ID Title Journal Year
9845364 A novel function for SMN, the spinal muscular atrophy disease gene product, in pre-mRNA splicing

Kataoka, N, Dreyfuss, G, Charroux, B, Pellizzoni, L

Cell 1998
12441251 SMN-mediated assembly of RNPs: a complex story

Eggert, C, Fischer, U, Meister, G

Trends Cell Biol 2002
10556282 Essential role for the tudor domain of SMN in spliceosomal U snRNP assembly: implications for spinal muscular atrophy

Luhrmann, R, Buhler, D, Raker, V, Fischer, U

Hum Mol Genet 1999
Participants
Participates
Event Information
This event is regulated
Authored
Reviewed
Created
Cite Us!