Reactome | SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol

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SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol Show undefined attributes

authored	[InstanceEdit:189111] D'Eustachio, P, 2006-11-03 14:36:07
catalystActivity	[CatalystActivity:428653] D-glucose:sodium symporter activity of SLC5A2 [plasma membrane]
catalystActivityReference	[CatalystActivityReference:9643224] glucose:sodium symporter activity of SLC5A2 [plasma membrane] Renal Na(+)-glucose cotransporters
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:189226] D'Eustachio, P, 2006-11-04 20:44:47
crossReference	[DatabaseIdentifier:12668079] RHEA:70571
dbId	189208
displayName	SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol
edited	[InstanceEdit:189226] D'Eustachio, P, 2006-11-04 20:44:47
eventOf	[Pathway:R-HSA-189200] Cellular hexose transport - Homo sapiens
input	[SimpleEntity:R-ALL-70115] Glc [extracellular region] [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:429604] Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive renal glucosuria [LiteratureReference:189223] Functional asymmetry of the human Na+/glucose transporter (hSGLT1) in bacterial membrane vesicles [LiteratureReference:429653] SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose [LiteratureReference:8981518] SGLT2 mediates glucose reabsorption in the early proximal tubule [LiteratureReference:8981517] Renal Na(+)-glucose cotransporters
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol
negativePrecedingEvent	[NegativePrecedingEvent:9963432] Futile Cycle: GLUT2 (SLC2A2) transports Glc from cytosol to extracellular region [NegativePrecedingEvent:9963452] Futile Cycle: SLC50A1 transports Glc from cytosol to extracellular region
orthologousEvent	[Reaction:R-GGA-189208] SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol - Gallus gallus [Reaction:R-XTR-189208] SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol - Xenopus tropicalis [Reaction:R-DRE-189208] SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol - Danio rerio [Reaction:R-SSC-189208] SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol - Sus scrofa [Reaction:R-BTA-189208] SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol - Bos taurus [Reaction:R-CFA-189208] SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol - Canis familiaris [Reaction:R-RNO-189208] SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol - Rattus norvegicus [Reaction:R-MMU-189208] SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol - Mus musculus
output	[SimpleEntity:R-ALL-70113] Glc [cytosol] [SimpleEntity:R-ALL-83910] Na+ [cytosol]
releaseDate	2006-01-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:191112] Wright, EM, 2007-01-15 21:00:45
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-189208
summation	[Summation:189198] SLC5A2 (also known as SGLT2) in the plasma membrane co-trans...
updateTrackers	[UpdateTracker:9791436] Update Tracker - [Reaction:189208] SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol - v30:[addCatalystActivity, removeRegulator] [UpdateTracker:9781482] Update Tracker - [Reaction:189208] SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol - v61:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]

Referrals

(updatedInstance)	[UpdateTracker:9791436] Update Tracker - [Reaction:189208] SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol - v30:[addCatalystActivity, removeRegulator] [UpdateTracker:9781482] Update Tracker - [Reaction:189208] SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol - v61:[addLiteratureReference, add_removeInput, add_removeOutput, modifyText]
(hasEvent)	[Pathway:R-HSA-189200] Cellular hexose transport
(precedingEvent)	[NegativePrecedingEvent:9963448] Futile Cycle: SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol [NegativePrecedingEvent:9963439] Futile Cycle: SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol

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