Reactome | SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol

SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol

Stable Identifier

R-HSA-189208

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol

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SLC5A2 (also known as SGLT2) in the plasma membrane co-transports extracellular sodium ions (Na+) and glucose (Glc) into the cytosol (Quick et al. 2003; Wright 2001). SLC5A2 is expressed at high levels in the kidney (Tazawa et al. 2005) and appears to be the major mediator of kidney glucose reabsorption. Human patients who lack functional SLC5A2 (e.g., Calado et al. 2004) and mouse strains lacking its homolog (Vallon et al. 2011) excrete abnormally large amounts of glucose in the urine but exhibit normal uptake of dietary glucose.

Literature References

PubMed ID	Title	Journal	Year
20616166	SGLT2 mediates glucose reabsorption in the early proximal tubule Vallon, V, Platt, KA, Cunard, R, Schroth, J, Whaley, J, Thomson, SC, Koepsell, H, Rieg, T	J. Am. Soc. Nephrol.	2011
12885248	Functional asymmetry of the human Na+/glucose transporter (hSGLT1) in bacterial membrane vesicles Quick, M, Tomasevic, J, Wright, EM	Biochemistry	2003
11133510	Renal Na(+)-glucose cotransporters Wright, EM	Am. J. Physiol. Renal Physiol.	2001
15607332	SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose Tazawa, S, Yamato, T, Fujikura, H, Hiratochi, M, Itoh, F, Tomae, M, Takemura, Y, Maruyama, H, Sugiyama, T, Wakamatsu, A, Isogai, T, Isaji, M	Life Sci	2005
14614622	Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive renal glucosuria Calado, J, Soto, K, Clemente, C, Correia, P, Rueff, J	Hum Genet	2004