SLC5A2 cotransports Na+ and glucose from extracellular region to cytosol

Stable Identifier
R-HSA-189208
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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SLC5A2 (also known as SGLT2) in the plasma membrane co-transports extracellular sodium ions (Na+) and glucose (Glc) into the cytosol (Quick et al. 2003; Wright 2001). SLC5A2 is expressed at high levels in the kidney (Tazawa et al. 2005) and appears to be the major mediator of kidney glucose reabsorption. Human patients who lack functional SLC5A2 (e.g., Calado et al. 2004) and mouse strains lacking its homolog (Vallon et al. 2011) excrete abnormally large amounts of glucose in the urine but exhibit normal uptake of dietary glucose.

Literature References
PubMed ID Title Journal Year
12885248 Functional asymmetry of the human Na+/glucose transporter (hSGLT1) in bacterial membrane vesicles

Quick, M, Tomasevic, J, Wright, EM

Biochemistry 2003
20616166 SGLT2 mediates glucose reabsorption in the early proximal tubule

Vallon, V, Platt, KA, Cunard, R, Schroth, J, Whaley, J, Thomson, SC, Koepsell, H, Rieg, T

J. Am. Soc. Nephrol. 2011
11133510 Renal Na(+)-glucose cotransporters

Wright, EM

Am. J. Physiol. Renal Physiol. 2001
15607332 SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose

Tazawa, S, Yamato, T, Fujikura, H, Hiratochi, M, Itoh, F, Tomae, M, Takemura, Y, Maruyama, H, Sugiyama, T, Wakamatsu, A, Isogai, T, Isaji, M

Life Sci 2005
14614622 Novel compound heterozygous mutations in SLC5A2 are responsible for autosomal recessive renal glucosuria

Calado, J, Soto, K, Clemente, C, Correia, P, Rueff, J

Hum Genet 2004
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
glucose:sodium symporter activity of SLC5A2 [plasma membrane]
Physical Entity
Activity
Orthologous Events
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Reviewed
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