Reactome | sucrose + H2O => glucose + fructose

Schema > Reaction > Entries

sucrose + H2O => glucose + fructose Show undefined attributes

authored	[InstanceEdit:189111] D'Eustachio, P, 2006-11-03 14:36:07
catalystActivity	[CatalystActivity:189029] sucrose alpha-glucosidase activity of sucrase-isomaltase dimer [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:189008] D'Eustachio, P, 2006-11-03 14:39:28
dbId	189069
diseaseReaction	[FailedReaction:R-HSA-5659926] Defective SI does not hydrolyze Suc - Homo sapiens
displayName	sucrose + H2O => glucose + fructose
eventOf	[Pathway:R-HSA-189085] Digestion of dietary carbohydrate - Homo sapiens
followingEvent	[Reaction:R-HSA-189222] SLC2A5 transports fructose from extracellular region to cytosol - Homo sapiens [Reaction:R-HSA-8932955] SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-109276] H2O [extracellular region] [SimpleEntity:R-ALL-188980] Suc [extracellular region]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:188987] Expression and intracellular transport of microvillus membrane hydrolases in human intestinal epithelial cells [LiteratureReference:189047] Human intestinal sucrase-isomaltase. Identification of free sucrase and isomaltase and cleavage of the hybrid into active distinct subunits.
maxDepth	1
modified	[InstanceEdit:11051501] Weiser, Joel, 2026-03-16
name	sucrose + H2O => glucose + fructose Digestion of sucrose to yield glucose and fructose
orthologousEvent	[Reaction:R-SPO-189069] sucrose + H2O => glucose + fructose - Schizosaccharomyces pombe [Reaction:R-DDI-189069] sucrose + H2O => glucose + fructose - Dictyostelium discoideum [Reaction:R-CEL-189069] sucrose + H2O => glucose + fructose - Caenorhabditis elegans [Reaction:R-GGA-189069] sucrose + H2O => glucose + fructose - Gallus gallus [Reaction:R-XTR-189069] sucrose + H2O => glucose + fructose - Xenopus tropicalis [Reaction:R-SSC-189069] sucrose + H2O => glucose + fructose - Sus scrofa [Reaction:R-BTA-189069] sucrose + H2O => glucose + fructose - Bos taurus [Reaction:R-CFA-189069] sucrose + H2O => glucose + fructose - Canis familiaris [Reaction:R-RNO-189069] sucrose + H2O => glucose + fructose - Rattus norvegicus [Reaction:R-MMU-189069] sucrose + H2O => glucose + fructose - Mus musculus
output	[SimpleEntity:R-ALL-189049] Fru [extracellular region] [SimpleEntity:R-ALL-70115] Glc [extracellular region]
releaseDate	2007-02-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:191109] Nichols, BL, 2007-01-15 21:51:24
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-189069
summation	[Summation:188988] Extracellular sucrose is hydrolyzed to yield glucose and fru...

Referrals

(normalReaction)	[FailedReaction:R-HSA-5659926] Defective SI does not hydrolyze Suc
(precedingEvent)	[Reaction:R-HSA-189222] SLC2A5 transports fructose from extracellular region to cytosol [Reaction:R-HSA-8932955] SLC5A1 cotransports Glc,Gal with Na+ from extracellular region to cytosol
(hasEvent)	[Pathway:R-HSA-189085] Digestion of dietary carbohydrate