Reactome | XYLTs transfer Xyl to core protein

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XYLTs transfer Xyl to core protein Show undefined attributes

authored	[InstanceEdit:1877997] Jassal, Bijay, 2011-10-31
catalystActivity	[CatalystActivity:1877999] protein xylosyltransferase activity of XYLT1, XYLT2 [Golgi membrane]
category	transition
compartment	[Compartment:20699] Golgi membrane [Compartment:17963] Golgi lumen
created	[InstanceEdit:1877997] Jassal, Bijay, 2011-10-31
crossReference	[DatabaseIdentifier:9941498] RHEA:50193
dbId	1878002
displayName	XYLTs transfer Xyl to core protein
edited	[InstanceEdit:1877997] Jassal, Bijay, 2011-10-31
eventOf	[Pathway:R-HSA-1971475] Glycosaminoglycan-protein linkage region biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-1889981] B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker - Homo sapiens
input	[DefinedSet:R-HSA-2054107] GAG core proteins [Golgi lumen] [SimpleEntity:R-ALL-742361] UDP-Xyl [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1878004] Analysis of the DXD motifs in human xylosyltransferase I required for enzyme activity [LiteratureReference:1878003] Human xylosyltransferase I: functional and biochemical characterization of cysteine residues required for enzymic activity [LiteratureReference:1889964] Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II [LiteratureReference:8863597] XT-II, the second isoform of human peptide-O-xylosyltransferase, displays enzymatic activity
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	XYLTs transfer Xyl to core protein Xylose is transferred to a serine residue on the core protein
orthologousEvent	[Reaction:R-BTA-1878002] XYLTs transfer Xyl to core protein - Bos taurus [Reaction:R-CEL-1878002] XYLTs transfer Xyl to core protein - Caenorhabditis elegans [Reaction:R-DME-1878002] XYLTs transfer Xyl to core protein - Drosophila melanogaster [Reaction:R-GGA-1878002] XYLTs transfer Xyl to core protein - Gallus gallus [Reaction:R-XTR-1878002] XYLTs transfer Xyl to core protein - Xenopus tropicalis [Reaction:R-DRE-1878002] XYLTs transfer Xyl to core protein - Danio rerio [Reaction:R-SSC-1878002] XYLTs transfer Xyl to core protein - Sus scrofa [Reaction:R-CFA-1878002] XYLTs transfer Xyl to core protein - Canis familiaris [Reaction:R-RNO-1878002] XYLTs transfer Xyl to core protein - Rattus norvegicus [Reaction:R-MMU-1878002] XYLTs transfer Xyl to core protein - Mus musculus
output	[SimpleEntity:R-ALL-425969] H+ [Golgi lumen] [SimpleEntity:R-ALL-205687] UDP [Golgi lumen] [DefinedSet:R-HSA-2064201] xylosyl-core proteins [Golgi lumen]
precedingEvent	[Reaction:R-HSA-742373] SLC35B4 mediates the transport of UDP-xylose into the Golgi lumen - Homo sapiens [Reaction:R-HSA-8863761] UXS1 tetramer decarboxylates UDP-glucuronate to UDP-xylose - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2172129] D'Eustachio, P, 2012-03-28 [InstanceEdit:9941989] D'Eustachio, Peter, 2025-03-12
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1878002
summation	[Summation:1877989] Xylosyltransferases (XYLT1, XYLT2) catalyse the initial step...
updateTrackers	[UpdateTracker:9783027] Update Tracker - [Reaction:1878002] XYLTs transfer Xyl to core protein - v57:[addLiteratureReference, modifyText] [UpdateTracker:9953643] Update Tracker - [Reaction:1878002] XYLTs transfer Xyl to core protein - v93:[modifyText, removeOutput]

Referrals

(updatedInstance)	[UpdateTracker:9783027] Update Tracker - [Reaction:1878002] XYLTs transfer Xyl to core protein - v57:[addLiteratureReference, modifyText] [UpdateTracker:9953643] Update Tracker - [Reaction:1878002] XYLTs transfer Xyl to core protein - v93:[modifyText, removeOutput]
(hasEvent)	[Pathway:R-HSA-1971475] Glycosaminoglycan-protein linkage region biosynthesis
(precedingEvent)	[Reaction:R-HSA-1889981] B4GALT7 transfers Gal group to xylosyl-unit of the tetrasaccharide linker

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