XYLTs transfer Xyl to core protein

Stable Identifier
Reaction [transition]
Homo sapiens
Xylose is transferred to a serine residue on the core protein
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Xylosyltransferases (XYLT1, XYLT2) catalyse the initial step in the tetrasaccharide linkage required for glycosaminoglycan biosynthesis. This reaction can take place in the Golgi apparatus and endoplasmic reticulum (not shown here). XYLTs mediates the transfer of xylose from the active nucleotide sugar UDP-xylose to specific serine hydroxy groups in the core protein. A C-terminal DxD motif on the enzyme is thought to be critical for activity (Muller et al. 2005, Goetting et al. 2004, Voglmeir et al. 2007).

Literature References
PubMed ID Title Journal Year
17194707 XT-II, the second isoform of human peptide-O-xylosyltransferase, displays enzymatic activity

Voglmeir, J, Voglauer, R, Wilson, IB

J. Biol. Chem. 2007
15461586 Human xylosyltransferase I: functional and biochemical characterization of cysteine residues required for enzymic activity

Müller, S, Schöttler, M, Schön, S, Prante, C, Brinkmann, T, Kuhn, J, Götting, C, Kleesiek, K

Biochem J 2005
15294915 Analysis of the DXD motifs in human xylosyltransferase I required for enzyme activity

Götting, C, Müller, S, Schöttler, M, Schön, S, Prante, C, Brinkmann, T, Kuhn, J, Kleesiek, K

J Biol Chem 2004
11099377 Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II

Götting, C, Kuhn, J, Zahn, R, Brinkmann, T, Kleesiek, K

J Mol Biol 2000
Catalyst Activity

protein xylosyltransferase activity of XYLT1, XYLT2 [Golgi membrane]

Orthologous Events
Cite Us!