XYLTs transfer Xyl to core protein

Stable Identifier
R-HSA-1878002
Type
Reaction [transition]
Species
Homo sapiens
Compartment
Golgi membrane, Golgi lumen
Synonyms
Xylose is transferred to a serine residue on the core protein
ReviewStatus
5/5
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XYLTs transfer Xyl to core protein
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Xylosyltransferases (XYLT1, XYLT2) catalyse the initial step in the tetrasaccharide linkage required for glycosaminoglycan biosynthesis. This reaction can take place in the Golgi apparatus and endoplasmic reticulum (not shown here). XYLTs mediates the transfer of xylose from the active nucleotide sugar UDP-xylose to specific serine hydroxy groups in the core protein. A C-terminal DxD motif on the enzyme is thought to be critical for activity (Muller et al. 2005, Goetting et al. 2004, Voglmeir et al. 2007).
Literature References
PubMed ID Title Journal Year
15461586 Human xylosyltransferase I: functional and biochemical characterization of cysteine residues required for enzymic activity

Kuhn, J, Brinkmann, T, Prante, C, Schön, S, Götting, C, Kleesiek, K, Müller, S, Schöttler, M

Biochem J 2005
17194707 XT-II, the second isoform of human peptide-O-xylosyltransferase, displays enzymatic activity

Voglmeir, J, Voglauer, R, Wilson, IB

J. Biol. Chem. 2007
15294915 Analysis of the DXD motifs in human xylosyltransferase I required for enzyme activity

Kuhn, J, Brinkmann, T, Prante, C, Schön, S, Götting, C, Kleesiek, K, Müller, S, Schöttler, M

J Biol Chem 2004
11099377 Molecular cloning and expression of human UDP-d-Xylose:proteoglycan core protein beta-d-xylosyltransferase and its first isoform XT-II

Kuhn, J, Brinkmann, T, Götting, C, Kleesiek, K, Zahn, R

J Mol Biol 2000
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein xylosyltransferase activity of XYLT1, XYLT2 [Golgi membrane]

Physical Entity
XYLT1, XYLT2 [Golgi membrane] (Homo sapiens)
Activity
protein xylosyltransferase activity (GO:0030158)
Orthologous Events
XYLTs transfer Xyl to core protein (Bos taurus)
XYLTs transfer Xyl to core protein (Caenorhabditis elegans)
XYLTs transfer Xyl to core protein (Canis familiaris)
XYLTs transfer Xyl to core protein (Danio rerio)
XYLTs transfer Xyl to core protein (Drosophila melanogaster)
XYLTs transfer Xyl to core protein (Gallus gallus)
XYLTs transfer Xyl to core protein (Mus musculus)
XYLTs transfer Xyl to core protein (Rattus norvegicus)
XYLTs transfer Xyl to core protein (Sus scrofa)
XYLTs transfer Xyl to core protein (Xenopus tropicalis)
Authored
Jassal, B  (2011-10-31)
Reviewed
D'Eustachio, P  (2012-03-28)
Created
Jassal, B  (2011-10-31)
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