Reactome | 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol

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1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol Show undefined attributes

authored	[InstanceEdit:1855226] Williams, MG, 2011-10-28
catalystActivity	[CatalystActivity:2023982] diphosphoinositol tetrakisphosphate kinase activity of IP6K1/3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1855226] Williams, MG, 2011-10-28
dbId	1855193
displayName	1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol
edited	[InstanceEdit:1855226] Williams, MG, 2011-10-28
eventOf	[Pathway:R-HSA-1855167] Synthesis of pyrophosphates in the cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-1629736] 1-PP-IP4 [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1889803] Identification and characterization of a novel inositol hexakisphosphate kinase [LiteratureReference:1889872] The inositol hexakisphosphate kinase family. Catalytic flexibility and function in yeast vacuole biogenesis [LiteratureReference:1889876] Inositol hexakisphosphate kinase products contain diphosphate and triphosphate groups
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol
orthologousEvent	[Reaction:R-PFA-1855193] 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol - Plasmodium falciparum [Reaction:R-SCE-1855193] 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol - Saccharomyces cerevisiae [Reaction:R-SPO-1855193] 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol - Schizosaccharomyces pombe [Reaction:R-DDI-1855193] 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol - Dictyostelium discoideum [Reaction:R-CEL-1855193] 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol - Caenorhabditis elegans [Reaction:R-DME-1855193] 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol - Drosophila melanogaster [Reaction:R-GGA-1855193] 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol - Gallus gallus [Reaction:R-XTR-1855193] 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol - Xenopus tropicalis [Reaction:R-DRE-1855193] 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol - Danio rerio [Reaction:R-SSC-1855193] 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol - Sus scrofa [Reaction:R-BTA-1855193] 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol - Bos taurus [Reaction:R-CFA-1855193] 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol - Canis familiaris [Reaction:R-RNO-1855193] 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol - Rattus norvegicus [Reaction:R-MMU-1855193] 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol - Mus musculus
output	[SimpleEntity:R-ALL-1629738] 1,5-(PP)2-IP3 [cytosol] [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-HSA-1855173] 5-PP-IP4 transports from the nucleus to the cytosol - Homo sapiens [Reaction:R-HSA-1855223] I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol - Homo sapiens
releaseDate	2012-12-04
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2562610] Wundenberg, Torsten, 2012-11-06
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1855193
summation	[Summation:2023964] Inositol hexakisphosphate kinase 1 (IP6K1) and 3 (IP6K3) pho...

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[Pathway:R-HSA-1855167] Synthesis of pyrophosphates in the cytosol

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