Reactome | 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol

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1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10864827] diphosphoinositol tetrakisphosphate kinase activity of IP6K1/3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
dbId	10864829
displayName	1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol
eventOf	[Pathway:R-DME-1855167] Synthesis of pyrophosphates in the cytosol - Drosophila melanogaster
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1855193] 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-1629736] 1-PP-IP4 [cytosol] [SimpleEntity:R-ALL-113592] ATP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol
output	[SimpleEntity:R-ALL-1629738] 1,5-(PP)2-IP3 [cytosol] [SimpleEntity:R-ALL-29370] ADP [cytosol]
precedingEvent	[Reaction:R-DME-1855173] 5-PP-IP4 transports from the nucleus to the cytosol - Drosophila melanogaster [Reaction:R-DME-1855223] I(1,3,4,5,6)P5 is phosphorylated to 5-PP-IP4 by IP6K1/3 in the cytosol - Drosophila melanogaster
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:56210] Drosophila melanogaster
stId	R-DME-1855193
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-DME-1855167] Synthesis of pyrophosphates in the cytosol
(inferredTo)	[Reaction:R-HSA-1855193] 1-PP-IP4 is phosphorylated to 1,5-(PP)2-IP3 by IP6K1/3 in the cytosol

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