Reactome | EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane]

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EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] Show undefined attributes

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-HSA-8866253] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane] - Homo sapiens
created	[InstanceEdit:182919] Jassal, B, 2006-07-21 10:17:37
dbId	182945
displayName	EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane]
hasComponent	2 × [DefinedSet:R-HSA-9624194] EGF-like ligands [extracellular region] 2 × [EntityWithAccessionedSequence:R-HSA-179803] p-6Y-EGFR [plasma membrane] 2 × [Complex:R-HSA-182964] p-Y371-CBL:GRB2 [cytosol] 2 × [DefinedSet:R-HSA-113595] Ub [cytosol]
inDisease	false
includedLocation	[Compartment:70101] cytosol [Compartment:984] extracellular region
inferredTo	[Complex:R-MMU-182945] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] - Mus musculus [Complex:R-RNO-182945] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] - Rattus norvegicus [Complex:R-CFA-182945] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] - Canis familiaris [Complex:R-BTA-182945] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] - Bos taurus [Complex:R-SSC-182945] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] - Sus scrofa [Complex:R-DRE-182945] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] - Danio rerio [Complex:R-XTR-182945] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] - Xenopus tropicalis [Complex:R-GGA-182945] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] - Gallus gallus [Complex:R-DME-182945] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] - Drosophila melanogaster [Complex:R-CEL-182945] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] - Caenorhabditis elegans
maxDepth	3
modified	[InstanceEdit:9824819] Orlic-Milacic, Marija, 2023-01-22
name	EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 EGF:Phospho-EGFR (Y1069) dimer Ubiquitinated:Phospho-CBL:GRB2 EGF:Phospho-EGFR (Y1045) dimer Ubiquitinated:Phospho-CBL:GRB2
producedByEvent	[Reaction:R-HSA-183036] Ubiquitination of stimulated EGFR (CBL:GRB2) - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-182945
updateTrackers	[UpdateTracker:9870425] Update Tracker - [Complex:182945] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] - v38:[addName, add_removeHasComponent] [UpdateTracker:9891113] Update Tracker - [Complex:182945] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] - v52:[updateContainedComponent] [UpdateTracker:9900025] Update Tracker - [Complex:182945] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] - v67:[add_removeHasComponent, modifyName] [UpdateTracker:9904967] Update Tracker - [Complex:182945] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] - v84:[addName] [UpdateTracker:9879805] Update Tracker - [Complex:182945] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] - v44:[updateContainedComponent] [UpdateTracker:9869790] Update Tracker - [Complex:182945] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] - v34:[updateContainedComponent]

Referrals

(updatedInstance)	[UpdateTracker:9870425] Update Tracker - [Complex:182945] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] - v38:[addName, add_removeHasComponent] [UpdateTracker:9891113] Update Tracker - [Complex:182945] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] - v52:[updateContainedComponent] [UpdateTracker:9900025] Update Tracker - [Complex:182945] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] - v67:[add_removeHasComponent, modifyName] [UpdateTracker:9904967] Update Tracker - [Complex:182945] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] - v84:[addName] [UpdateTracker:9879805] Update Tracker - [Complex:182945] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] - v44:[updateContainedComponent] [UpdateTracker:9869790] Update Tracker - [Complex:182945] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2 [plasma membrane] - v34:[updateContainedComponent]
(hasComponent)	[Complex:R-HSA-8866253] EGF-like ligands:Ub-p-6Y-EGFR:p-Y371-CBL:GRB2:REPS2 [plasma membrane]
(output)	[Reaction:R-HSA-183036] Ubiquitination of stimulated EGFR (CBL:GRB2)

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