Reactome | Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)

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Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) Show undefined attributes

authored	[InstanceEdit:381396] May, B, Gopinathrao, G, 2008-11-19 19:22:37
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:1799328] D'Eustachio, P, 2011-10-23
dbId	1799332
deleted	[Deleted:1799345] Deletion of instance: 264942
displayName	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)
edited	[InstanceEdit:381396] May, B, Gopinathrao, G, 2008-11-19 19:22:37
eventOf	[Pathway:R-HSA-1799339] SRP-dependent cotranslational protein targeting to membrane - Homo sapiens
followingEvent	[Reaction:R-HSA-1799330] The SRP receptor binds the SRP:nascent peptide:ribosome complex - Homo sapiens
input	[Complex:R-HSA-1799327] ribosome:mRNA:polypeptide+signal [cytosol] [Complex:R-HSA-264932] Signal Recognition Particle [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:264328] Structure, function and evolution of the signal recognition particle [LiteratureReference:445223] SRP keeps polypeptides translocation-competent by slowing translation to match limiting ER-targeting sites [LiteratureReference:445226] Human autoantibodies against the 54 kDa protein of the signal recognition particle block function at multiple stages
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)
orthologousEvent	[Reaction:R-PFA-1799332] Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) - Plasmodium falciparum [Reaction:R-SCE-1799332] Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) - Saccharomyces cerevisiae [Reaction:R-SPO-1799332] Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) - Schizosaccharomyces pombe [Reaction:R-DDI-1799332] Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) - Dictyostelium discoideum [Reaction:R-CEL-1799332] Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) - Caenorhabditis elegans [Reaction:R-DME-1799332] Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) - Drosophila melanogaster [Reaction:R-GGA-1799332] Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) - Gallus gallus [Reaction:R-XTR-1799332] Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) - Xenopus tropicalis [Reaction:R-DRE-1799332] Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) - Danio rerio [Reaction:R-SSC-1799332] Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) - Sus scrofa [Reaction:R-BTA-1799332] Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) - Bos taurus [Reaction:R-CFA-1799332] Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) - Canis familiaris [Reaction:R-RNO-1799332] Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) - Rattus norvegicus [Reaction:R-MMU-1799332] Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) - Mus musculus
output	[Complex:R-HSA-1799337] SRP:polypeptide+signal:ribosome [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-1799335] Synthesis of nascent polypeptide containing signal sequence - Homo sapiens
releaseDate	2008-12-17
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:387470] D'Eustachio, P, Matthews, L, Gillespie, ME, 2008-12-02 16:25:31
revised	[InstanceEdit:1799331] D'Eustachio, P, 2011-10-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-1799332
summation	[Summation:2129002] The Ribosome Nascent Complex containing the ribosome and pro...
updateTrackers	[UpdateTracker:9788854] Update Tracker - [Reaction:1799332] Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) - v40:[add_removeSummation]

Referrals

(updatedInstance)	[UpdateTracker:9788854] Update Tracker - [Reaction:1799332] Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) - v40:[add_removeSummation]
(replacementInstances)	[Deleted:1799345] Deletion of instance: 264942
(hasEvent)	[Pathway:R-HSA-1799339] SRP-dependent cotranslational protein targeting to membrane
(precedingEvent)	[Reaction:R-HSA-1799330] The SRP receptor binds the SRP:nascent peptide:ribosome complex

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