Reactome | Signal Recognition Particle [cytosol]

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Signal Recognition Particle [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-HSA-1799337] SRP:polypeptide+signal:ribosome [cytosol] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-1799332] Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP) - Homo sapiens
created	[InstanceEdit:265053] May, B, 2008-04-15 03:12:38
crossReference	[DatabaseIdentifier:11891548] ComplexPortal:CPX-2652
dbId	264932
displayName	Signal Recognition Particle [cytosol]
goCellularComponent	[GO_CellularComponent:17955] signal recognition particle, endoplasmic reticulum targeting
hasComponent	[DefinedSet:R-HSA-445238] 7SL RNA [cytosol] [EntityWithAccessionedSequence:R-HSA-264941] SRP14 [cytosol] [EntityWithAccessionedSequence:R-HSA-264956] SRP19 [cytosol] [EntityWithAccessionedSequence:R-HSA-264977] SRP54 [cytosol] [EntityWithAccessionedSequence:R-HSA-445234] SRP68 [cytosol] [EntityWithAccessionedSequence:R-HSA-265069] SRP72 [cytosol] [EntityWithAccessionedSequence:R-HSA-265038] SRP9 [cytosol]
inDisease	false
inferredTo	[Complex:R-MMU-264932] Signal Recognition Particle [cytosol] - Mus musculus [Complex:R-RNO-264932] Signal Recognition Particle [cytosol] - Rattus norvegicus [Complex:R-CFA-264932] Signal Recognition Particle [cytosol] - Canis familiaris [Complex:R-BTA-264932] Signal Recognition Particle [cytosol] - Bos taurus [Complex:R-SSC-264932] Signal Recognition Particle [cytosol] - Sus scrofa [Complex:R-DRE-264932] Signal Recognition Particle [cytosol] - Danio rerio [Complex:R-XTR-264932] Signal Recognition Particle [cytosol] - Xenopus tropicalis [Complex:R-GGA-264932] Signal Recognition Particle [cytosol] - Gallus gallus [Complex:R-DME-264932] Signal Recognition Particle [cytosol] - Drosophila melanogaster [Complex:R-CEL-264932] Signal Recognition Particle [cytosol] - Caenorhabditis elegans [Complex:R-DDI-264932] Signal Recognition Particle [cytosol] - Dictyostelium discoideum [Complex:R-SPO-264932] Signal Recognition Particle [cytosol] - Schizosaccharomyces pombe [Complex:R-SCE-264932] Signal Recognition Particle [cytosol] - Saccharomyces cerevisiae [Complex:R-PFA-264932] Signal Recognition Particle [cytosol] - Plasmodium falciparum
literatureReference	[LiteratureReference:445236] Induced structural changes of 7SL RNA during the assembly of human signal recognition particle [LiteratureReference:445240] Protein-induced conformational changes of RNA during the assembly of human signal recognition particle [LiteratureReference:445242] Characterization of the SRP68/72 interface of human signal recognition particle by systematic site-directed mutagenesis [LiteratureReference:445257] Identification of the RNA binding regions of SRP68/72 and SRP72 by systematic mutagenesis of human SRP RNA [LiteratureReference:445255] Assembly of the human signal recognition particle (SRP): overlap of regions required for binding of protein SRP54 and assembly control [LiteratureReference:445248] Visualizing induced fit in early assembly of the human signal recognition particle [LiteratureReference:445245] Expression, purification, and crystallography of the conserved methionine-rich domain of human signal recognition particle 54 kDa protein [LiteratureReference:445235] Human signal recognition particle (SRP) Alu-associated protein also binds Alu interspersed repeat sequence RNAs. Characterization of human SRP9 [LiteratureReference:445231] Recognition of a tetranucleotide loop of signal recognition particle RNA by protein SRP19 [LiteratureReference:445233] Targeting proteins to membranes: structure of the signal recognition particle
modified	[InstanceEdit:11891188] Wright, Adam, 2024-03-11
name	Signal Recognition Particle signal recognition particle, endoplasmic reticulum targeting
producedByEvent	[Reaction:R-HSA-1799326] Signal-containing nascent peptide translocates to endoplasmic reticulum - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-264932

Referrals

(input)	[Reaction:R-HSA-1799332] Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)
(output)	[Reaction:R-HSA-1799326] Signal-containing nascent peptide translocates to endoplasmic reticulum
(hasComponent)	[Complex:R-HSA-1799337] SRP:polypeptide+signal:ribosome [cytosol]

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