Reactome | SMAD7:SMURF1 complex is exported to the cytosol

Schema > Reaction > Entries

SMAD7:SMURF1 complex is exported to the cytosol Show undefined attributes

authored	[InstanceEdit:171270] Heldin, CH, Moustakas, A, Huminiecki, L, Jassal, B, 2006-02-02
catalystActivity	[CatalystActivity:178174] nuclear export signal receptor activity of SMAD7:SMURF1:XPO1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm [Compartment:70101] cytosol
created	[InstanceEdit:178182] Jassal, B, 2006-04-18 14:28:42
dbId	178215
displayName	SMAD7:SMURF1 complex is exported to the cytosol
edited	[InstanceEdit:2187413] Jassal, B, 2012-04-10
eventOf	[Pathway:R-HSA-2173788] Downregulation of TGF-beta receptor signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-178218] SMAD7:SMURF complex binds to phosphorylated TGFBR1 - Homo sapiens
inferredFrom	[Reaction:R-NUL-2169016] Smad7:SMURF1 complex translocates to the cytosol - Homo sapiens
input	[Complex:R-HSA-2167923] SMAD7:SMURF1:XPO1 [nucleoplasm]
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:178198] Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7 [LiteratureReference:178177] Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	SMAD7:SMURF1 complex is exported to the cytosol
output	[Complex:R-HSA-2167927] SMAD7:SMURF1 [cytosol] [EntityWithAccessionedSequence:R-HSA-165539] XPO1 [cytosol]
precedingEvent	[Reaction:R-HSA-2167924] SMAD7:SMURF1 complex binds XPO1 (CRM1) - Homo sapiens
releaseDate	2012-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:2250308] Huang, Tao, 2012-05-14
revised	[InstanceEdit:2186634] Orlic-Milacic, M, 2012-04-04
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-178215
summation	[Summation:2169023] After SMAD7:SMURF1 complex binds to XPO1 (CRM1) through the ...

Referrals

(precedingEvent)	[Reaction:R-HSA-178218] SMAD7:SMURF complex binds to phosphorylated TGFBR1
(hasEvent)	[Pathway:R-HSA-2173788] Downregulation of TGF-beta receptor signaling
(inferredTo)	[Reaction:R-NUL-2169016] Smad7:SMURF1 complex translocates to the cytosol

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