SMAD7:SMURF1 complex is exported to the cytosol

Stable Identifier
R-HSA-178215
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
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SMAD7:SMURF1 complex is exported to the cytosol
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After SMAD7:SMURF1 complex binds to XPO1 (CRM1) through the nuclear export signal (NES) in the C-terminus of SMURF1, XPO1 enables transport of SMAD7:SMURF1 to the cytosol (Suzuki et al. 2002, Tajima et al. 2003). A recombinant mouse Smad7 and recombinant human SMURF1 were used in these experiments.
Literature References
PubMed ID Title Journal Year
12519765 Chromosomal region maintenance 1 (CRM1)-dependent nuclear export of Smad ubiquitin regulatory factor 1 (Smurf1) is essential for negative regulation of transforming growth factor-beta signaling by Smad7

Yoshida, M, Miyazono, K, Yoneda, Y, Tajima, Y, Shinomiya, K, Goto, K, Sekimoto, T, Imamura, T

J Biol Chem 2003
12151385 Smurf1 regulates the inhibitory activity of Smad7 by targeting Smad7 to the plasma membrane

Miyazono, K, Murakami, G, Shimanuki, T, Fukuchi, M, Shikauchi, Y, Imamura, T, Suzuki, C

J Biol Chem 2002
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Catalyst Activity

nuclear export signal receptor activity of SMAD7:SMURF1:XPO1 [nucleoplasm]

Physical Entity
SMAD7:SMURF1:XPO1 [nucleoplasm] (Homo sapiens)
Activity
nuclear export signal receptor activity (GO:0005049)
Inferred From
Smad7:SMURF1 complex translocates to the cytosol (Homo sapiens)
Authored
Jassal, B  (2006-02-02)
Huminiecki, L  (2006-02-02)
Moustakas, A  (2006-02-02)
Heldin, CH  (2006-02-02)
Reviewed
Huang, T  (2012-05-14)
Created
Jassal, B  (2006-04-18)
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