Reactome | N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP

Schema > Reaction > Entries

N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP Show undefined attributes

catalystActivity	[CatalystActivity:176520] sulfotransferase activity of SULTs active on NH2AAF [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:176534] D'Eustachio, P, 2006-03-08 20:43:01
dbId	176669
displayName	N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP
edited	[InstanceEdit:176810] D'Eustachio, P, 2006-03-11 18:40:17
eventOf	[Pathway:R-HSA-156584] Cytosolic sulfonation of small molecules - Homo sapiens
followingEvent	[Reaction:R-HSA-176606] Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate - Homo sapiens
input	[SimpleEntity:R-ALL-176566] N-hydroxy-2-acetylaminofluorene [cytosol] [SimpleEntity:R-ALL-158471] PAPS [cytosol]
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:176637] Sulfotransferases in the bioactivation of xenobiotics [LiteratureReference:176647] Molecular cloning, expression, and characterization of novel human SULT1C sulfotransferases that catalyze the sulfonation of N-hydroxy-2-acetylaminofluorene
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP
orthologousEvent	[Reaction:R-GGA-176669] N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP - Gallus gallus [Reaction:R-XTR-176669] N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP - Xenopus tropicalis [Reaction:R-DRE-176669] N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP - Danio rerio [Reaction:R-SSC-176669] N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP - Sus scrofa [Reaction:R-BTA-176669] N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP - Bos taurus [Reaction:R-CFA-176669] N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP - Canis familiaris [Reaction:R-RNO-176669] N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP - Rattus norvegicus [Reaction:R-MMU-176669] N-hydroxy-2-acetylaminofluorene + PAPS => 2-acetylaminofluorene-N-sulfate + PAP - Mus musculus
output	[SimpleEntity:R-ALL-176500] AAF-N-S [cytosol] [SimpleEntity:R-ALL-158466] PAP [cytosol]
precedingEvent	[Reaction:R-HSA-174389] PAPSS1,2 transfer PO4(2-) group from ATP to APS to form PAPS - Homo sapiens
releaseDate	2005-04-11
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:351775] D'Eustachio, P, 2008-05-28 08:30:54
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-176669
summation	[Summation:176670] Sulfonation of the xenobiotic N-hydroxy-2-acetylaminofluoren...

Referrals

(hasEvent)	[Pathway:R-HSA-156584] Cytosolic sulfonation of small molecules
(precedingEvent)	[Reaction:R-HSA-176606] Adenosine 3',5'-bisphosphate (PAP) + H2O => AMP + orthophosphate